Increased amplitude of hippocampal low frequency fluctuations in early psychosis: A two-year follow-up study.
Increased amplitude of hippocampal low frequency fluctuations in early psychosis: A two-year follow-up study.
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DOI：
10.1016/j.schres.2022.02.003
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发表时间：
2022-03
影响因子：
4.5
通讯作者：
Heckers S
中科院分区：
文献类型：
--
作者：
McHugo M;Rogers BP;Avery SN;Armstrong K;Blackford JU;Vandekar SN;Roeske MJ;Woodward ND;Heckers S
神经影像学研究揭示了精神分裂症患者的海马过度活跃。在疾病的早期阶段，海马体前部会出现过度活跃，并且随着疾病的进展，这种过度活跃被认为会扩散到其他区域。然而，关于精神病发作后基础海马功能发生变化的证据有限。静息状态功能性 MRI 信号幅度可能是新陈代谢增加和振荡活动破坏的替代指标，这两种情况都是海马过度活跃的兴奋/抑制失衡的后果。在这里，我们在一项为期两年的纵向病例对照研究中使用低频波动的分数幅度（fALFF）来检验进行性海马过度活跃的假设。我们在研究开始时发现非情感性精神病早期个体的前海马和后海马的 fALFF 较高。与我们的进行性海马功能障碍的假设相反，我们发现了精神病中 fALFF 随着时间的推移而正常化的证据。我们的研究结果支持这样一种模型：海马 fALFF 是精神病脆弱性或急性疾病状态的标志，而不是疾病的持久特征。
Neuroimaging studies have revealed hippocampal hyperactivity in schizophrenia. In the early stage of the illness, hyperactivity is present in the anterior hippocampus and is thought to spread to other regions as the illness progresses. However, there is limited evidence for changes in basal hippocampal function following the onset of psychosis. Resting state functional MRI signal amplitude may be a proxy measure for increased metabolism and disrupted oscillatory activity, both consequences of an excitation/inhibition imbalance underlying hippocampal hyperactivity. Here, we used fractional amplitude of low frequency fluctuations (fALFF) to test the hypothesis of progressive hippocampal hyperactivity in a two-year longitudinal case-control study. We found higher fALFF in the anterior and posterior hippocampus of individuals in the early stage of non-affective psychosis at study entry. Contrary to our hypothesis of progressive hippocampal dysfunction, we found evidence for normalization of fALFF over time in psychosis. Our findings support a model in which hippocampal fALFF is a marker of psychosis vulnerability or acute illness state rather than an enduring feature of the illness.
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影响因子：
4.5
作者：
Heckers, Stephan;Konradi, Christine
通讯作者：
Konradi, Christine
影响因子：
2.9
作者：
Blockley, Nicholas P.;Griffeth, Valerie E. M.;Simon, Aaron B.;Buxton, Richard B.
通讯作者：
Buxton, Richard B.
影响因子：
6.6
作者：
Avery, Suzanne N.;Armstrong, Kristan;Heckers, Stephan
通讯作者：
Heckers, Stephan
影响因子：
5.7
作者：
Aiello, Marco;Salvatore, Elena;Quarantelli, Mario
通讯作者：
Quarantelli, Mario
DOI：
10.1016/j.bpsc.2019.06.007
发表时间：
2019-11-01
影响因子：
5.9
作者：
Avery, Suzanne N.;McHugo, Maureen;Heckers, Stephan
通讯作者：
Heckers, Stephan