Lack of protective effect of chloroquine derivatives on COVID-19 disease in a Spanish sample of chronically treated patients.
Lack of protective effect of chloroquine derivatives on COVID-19 disease in a Spanish sample of chronically treated patients.
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DOI：
10.1371/journal.pone.0243598
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发表时间：
2020
期刊：
影响因子：
3.7
通讯作者：
Fibla J
中科院分区：
文献类型：
--
作者：
Laplana M;Yuguero O;Fibla J
寻找SARS-CoV-2治疗方法已成为全球优先事项。我们评估了氯喹及其衍生物在西班牙人COVID-19中的作用。我们对定期服用氯喹及其衍生物以控制自身免疫性疾病的患者进行了调查。该调查的分发特别关注以自身免疫性疾病和风湿病为中心的西班牙患者协会和一般人群。根据性别、年龄范围和发病地区，将未接受治疗的受试者样本与治疗组进行匹配。在治疗和未治疗的匹配对照样本之间比较COVID-19疾病患病率。共有319例定期服用氯喹及其衍生物的患者的调查被回收用于进一步分析。治疗组中宣布的COVID-19状态的患病率为5.3%，未治疗匹配组的平均患病率为3.4%。在治疗组（17.0% vs. 3.2%; p值<0.001）和未治疗组（13.4% vs. 1.1%; p值= 0.027）中，社区暴露于COVID-19与COVID-19的更高患病率相关。我们没有发现治疗组和未治疗组之间报告的COVID-19病例的差异，表明定期服用氯喹及其衍生药物对COVID-19感染缺乏保护作用。相关数据表明，定期服用氯喹衍生物的患者暴露于SARS-CoV-2感染，必须采取与普通人群相同的保护措施。
The search for a SARS-CoV-2 treatment has emerged as a worldwide priority. We evaluated the role of chloroquine and its derivatives in COVID-19 in Spanish individuals. We performed a survey addressed to patients regularly taking chloroquine and its derivatives for the control of their autoimmune diseases. The survey was distributed with special attention to Spanish patient associations centred on autoimmune diseases and rheumatology and to the general population. A sample of untreated subjects was matched to the treated group according to sex, age range and incidence region. COVID-19 disease prevalence was compared between treated and untreated-matched control sample. A total of 319 surveys of patients regularly taking chloroquine and its derivatives were recovered for further analysis. The prevalence of declared COVID-19 status in the treated group was 5.3% and the mean prevalence among the untreated-matched groups was 3.4%. A community exposition to COVID-19 was associated with a greater prevalence of COVID-19 in both, treated (17.0% vs. 3.2%; p-value<0.001) and untreated groups (13.4% vs. 1.1%; p-value = 0.027). We did not find differences of reported COVID-19 cases between treated and untreated groups, indicating a lack of protection by regular administration of chloroquine and its derivative drugs on COVID-19 infection. Of relevance, data indicates that patients that regularly take chloroquine derivatives are exposed to SARS-CoV-2 infection and must take the same protection measures as the general population.
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DOI：
10.1016/s1473-3099(03)00806-5
发表时间：
2003-11
期刊：
The Lancet. Infectious diseases
影响因子：
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作者：
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DOI：
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发表时间：
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