T cell-oriented strategies for controlling the COVID-19 pandemic.
T cell-oriented strategies for controlling the COVID-19 pandemic.
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DOI：
10.1038/s41577-021-00625-9
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发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Shin EC
中科院分区：
文献类型：
--
作者：
Noh JY;Jeong HW;Kim JH;Shin EC
COVID-19 疫苗接种计划正在全球范围内进行。中和抗体被认为是宿主抵御 COVID-19 的关键；然而，由于抗体滴度的衰减和 SARS-CoV-2 抗体逃逸变体的出现，仅注重中和抗体的策略可能不足以长期应对大流行。在这里，我们描述了 T 细胞在 COVID-19 中的保护作用以及 T 细胞表位在相关 SARS-CoV-2 变体中的保护，并讨论了面向 T 细胞的策略对控制 COVID-19 大流行的潜在贡献。鉴于疫苗接种或感染后中和抗体水平随着时间的推移而下降以及病毒逃逸变异的出现，这篇评论文章建议应考虑以 T 细胞为导向的疫苗策略来长期控制 COVID-19 大流行。
COVID-19 vaccination programmes are ongoing worldwide. Neutralizing antibodies are thought to be key for host protection against COVID-19; however, strategies that focus only on neutralizing antibodies may not be sufficient to cope with the pandemic in the longer term owing to the decay of antibody titres and the emergence of antibody-escape variants of SARS-CoV-2. Here, we describe the protective roles of T cells in COVID-19 and the conservation of T cell epitopes in SARS-CoV-2 variants of concern, and discuss the potential contribution of T cell-oriented strategies to controlling the COVID-19 pandemic. This Comment article proposes that T cell-oriented vaccine strategies should be considered to control the COVID-19 pandemic in the longer term, given declining levels of neutralizing antibodies with time after vaccination or infection and the emergence of viral escape variants.
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