Gaussian graphical modeling of the serum exposome and metabolome reveals interactions between environmental chemicals and endogenous metabolites.
Gaussian graphical modeling of the serum exposome and metabolome reveals interactions between environmental chemicals and endogenous metabolites.
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DOI：
10.1038/s41598-021-87070-9
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发表时间：
2021-04-07
影响因子：
4.6
通讯作者：
Rudel RA
中科院分区：
文献类型：
--
作者：
Bessonneau V;Gerona RR;Trowbridge J;Grashow R;Lin T;Buren H;Morello-Frosch R;Rudel RA
鉴于个体一生中经历的来自外源和内源的复杂暴露，询问生物标本中小分子水平的暴露范围的关联研究已被提议用于发现慢性病的原因。我们进行了一项研究，以探索环境化学物质和内源性分子之间的联系，使用非靶向代谢组学数据的高斯图形模型(GGMS)，在加州女性消防员和办公室工作人员的队列中进行测量。GGMS揭示了许多暴露与代谢物的关联，包括暴露于单羟基异酮邻苯二甲酸乙酯、对羟基苯甲酸乙酯和4-乙基苯甲酸与参与类固醇激素生物合成的代谢物有关，以及全氟烷基物质与胆汁酸(调节胆固醇和葡萄糖代谢的激素)和炎症信号分子有关。根据这些发现产生的一些假设通过对国家健康和营养检查调查数据的分析得到了证实。综上所述，我们的发现展示了一种新的方法来发现化学暴露与潜在的与疾病病因相关的生物过程之间的联系。
Given the complex exposures from both exogenous and endogenous sources that an individual experiences during life, exposome-wide association studies that interrogate levels of small molecules in biospecimens have been proposed for discovering causes of chronic diseases. We conducted a study to explore associations between environmental chemicals and endogenous molecules using Gaussian graphical models (GGMs) of non-targeted metabolomics data measured in a cohort of California women firefighters and office workers. GGMs revealed many exposure-metabolite associations, including that exposures to mono-hydroxyisononyl phthalate, ethyl paraben and 4-ethylbenzoic acid were associated with metabolites involved in steroid hormone biosynthesis, and perfluoroalkyl substances were linked to bile acids—hormones that regulate cholesterol and glucose metabolism—and inflammatory signaling molecules. Some hypotheses generated from these findings were confirmed by analysis of data from the National Health and Nutrition Examination Survey. Taken together, our findings demonstrate a novel approach to discovering associations between chemical exposures and biological processes of potential relevance for disease causation.
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DOI：
10.1016/j.apsb.2015.01.004
发表时间：
2015-03
期刊：
Acta pharmaceutica Sinica. B
影响因子：
--
作者：
Ding L;Yang L;Wang Z;Huang W
通讯作者：
Huang W
DOI：
10.1155/2013/657849
发表时间：
2013
期刊：
ISRN toxicology
影响因子：
--
作者：
Genuis SJ;Curtis L;Birkholz D
通讯作者：
Birkholz D
影响因子：
5.8
作者：
Chiang JY
通讯作者：
Chiang JY
影响因子：
10.4
作者：
Grandjean P;Heilmann C;Weihe P;Nielsen F;Mogensen UB;Budtz-Jørgensen E
通讯作者：
Budtz-Jørgensen E
DOI：
10.1038/jes.2017.28
发表时间：
2018-03-01
影响因子：
4.5
作者：
Gerona, Roy R.;Schwartz, Jackie M.;Woodruff, Tracey J.
通讯作者：
Woodruff, Tracey J.