Assessing Smoking Status and Risk of SARS-CoV-2 Infection: A Machine Learning Approach among Veterans.
Assessing Smoking Status and Risk of SARS-CoV-2 Infection: A Machine Learning Approach among Veterans.
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DOI：
10.3390/healthcare10071244
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发表时间：
2022-07-04
期刊：
影响因子：
2.8
通讯作者：
Amos, Christopher, I
中科院分区：
文献类型：
--
作者：
Djotsa, Alice B. S. Nono;Helmer, Drew A.;Park, Catherine;Lynch, Kristine E.;Sharafkhaneh, Amir;Naik, Aanand D.;Razjouyan, Javad;Amos, Christopher, I
吸烟在SARS-CoV-2感染风险中的作用尚不清楚。我们采用回顾性队列设计研究退伍军人电子病历数据，以评估吸烟对SARS-CoV-2感染风险的影响。从2020年2月1日至2021年2月28日接受SARS-CoV-2病毒检测的退伍军人被分类为：从不吸烟者（NS），前吸烟者（FS）和当前吸烟者（CS）。我们报告了从级联机器学习算法中获得的潜在混杂因素的调整优势比（aOR）。我们发现，在1，176，306名接受SARS-CoV-2感染检测的退伍军人中，阳性率为19.6%。NS组阳性率（22.0%）高于FS组（19.2%）和CS组（11.5%）。与NS相比，CS（aOR：0.51; 95%CI：0.50，0.52）和FS（aOR：0.89; 95%CI：0.88，0.90）检测阳性的调整比值显著降低。四种预先存在的疾病，包括痴呆症，下呼吸道感染，肺炎和感染性休克，与检测阳性的风险较高相关，而使用减充血剂药物苯巴比妥或有癌症史与风险较低相关。CS和FS与NS相比，SARS-CoV-2检测阳性的风险较低。这些发现强调了我们对吸烟状态对SARS-CoV-2感染风险的作用的不断发展的理解。
The role of smoking in the risk of SARS-CoV-2 infection is unclear. We used a retrospective cohort design to study data from veterans’ Electronic Medical Record to assess the impact of smoking on the risk of SARS-CoV-2 infection. Veterans tested for the SARS-CoV-2 virus from 02/01/2020 to 02/28/2021 were classified as: Never Smokers (NS), Former Smokers (FS), and Current Smokers (CS). We report the adjusted odds ratios (aOR) for potential confounders obtained from a cascade machine learning algorithm. We found a 19.6% positivity rate among 1,176,306 veterans tested for SARS-CoV-2 infection. The positivity proportion among NS (22.0%) was higher compared with FS (19.2%) and CS (11.5%). The adjusted odds of testing positive for CS (aOR:0.51; 95%CI: 0.50, 0.52) and FS (aOR:0.89; 95%CI:0.88, 0.90) were significantly lower compared with NS. Four pre-existing conditions, including dementia, lower respiratory infections, pneumonia, and septic shock, were associated with a higher risk of testing positive, whereas the use of the decongestant drug phenylephrine or having a history of cancer were associated with a lower risk. CS and FS compared with NS had lower risks of testing positive for SARS-CoV-2. These findings highlight our evolving understanding of the role of smoking status on the risk of SARS-CoV-2 infection.
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