'Moderate global aphasia': A generalized decline of language processing caused by glioma surgery but not stroke.
'Moderate global aphasia': A generalized decline of language processing caused by glioma surgery but not stroke.
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DOI：
10.1016/j.bandl.2021.105057
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发表时间：
2022-01
影响因子：
2.5
通讯作者：
Dragoy O
中科院分区：
文献类型：
--
作者：
Zyryanov A;Stupina E;Gordeyeva E;Buivolova O;Novozhilova E;Akinina Y;Bronov O;Gronskaya N;Gunenko G;Iskra E;Ivanova E;Kalinovskiy A;Kliuev E;Kopachev D;Kremneva E;Kryuchkova O;Medyanik I;Pedyash N;Pozdniakova V;Pronin I;Rainich K;Reutov A;Samoukina A;Shlyakhova A;Sitnikov A;Soloukhina O;Yashin K;Zelenkova V;Zuev A;Ivanova MV;Dragoy O
与中风不同，神经外科切除左半球胶质瘤作用于一个重组的语言网络，涉及很少被中风损害的脑区。我们探讨了这是否会导致神经外科手术和中风引起的语言障碍特征有所不同。对语言评估数据进行K - 均值聚类（神经外科队列：N = 88，中风队列：N = 95），在两个队列中都识别出了相似的特征。但关键的是，一组有特定语音缺陷的个体仅在中风队列中明显，而在神经外科队列中不明显。因此，与中风相比，胶质瘤手术后语音缺陷与其他语言缺陷的区分不那么明显。此外，在不同语言层面上，语言产生和理解分数之间的相关性在神经外科队列中比在中风队列中更广泛。我们的研究结果表明，神经外科手术引起的语言障碍与中风引起的语言障碍并不对应，而是表现为一种“中度全面性失语症”——语言处理能力的普遍下降。
Unlike stroke, neurosurgical removal of left-hemisphere gliomas acts upon a reorganized language network and involves brain areas rarely damaged by stroke. We addressed whether this causes the profiles of neurosurgery- and stroke-induced language impairments to be distinct. K-means clustering of language assessment data (neurosurgery cohort: N = 88, stroke cohort: N = 95) identified similar profiles in both cohorts. But critically, a cluster of individuals with specific phonological deficits was only evident in the stroke but not in the neurosurgery cohort. Thus, phonological deficits are less clearly distinguished from other language deficits after glioma surgery compared to stroke. Furthermore, the correlations between language production and comprehension scores at different linguistic levels were more extensive in the neurosurgery than in the stroke cohort. Our findings suggest that neurosurgery-induced language impairments do not correspond to those caused by stroke, but rather manifest as a ‘moderate global aphasia’ – a generalized decline of language processing abilities.
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