Immune Microenvironment in Osteosarcoma: Components, Therapeutic Strategies and Clinical Applications.
Immune Microenvironment in Osteosarcoma: Components, Therapeutic Strategies and Clinical Applications.
复制标题
骨肉瘤中的免疫微环境：成分、治疗策略和临床应用。
DOI：
10.3389/fimmu.2022.907550
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发表时间：
2022
影响因子：
7.3
通讯作者：
Xu, Jing
中科院分区：
文献类型：
--
作者：
Zhu, Tianyi;Han, Jing;Yang, Liu;Cai, Zhengdong;Sun, Wei;Hua, Yingqi;Xu, Jing
关键词：
骨肉瘤是一种易威胁儿童和青少年的原发性恶性肿瘤，近三十年来5年无事件生存率没有明显提高，给患者和社会带来了悲痛和经济负担。迄今为止，骨肉瘤的遗传背景和肿瘤发生机制仍不清楚，阻碍了进一步的研究。肿瘤免疫微环境已成为近年来的研究热点，为肿瘤异质性和肿瘤进展和转移的多方面机制提供了新的但有价值的见解。然而，骨肉瘤中的免疫微环境已被大力讨论，免疫和非免疫成分浸润的景观已被深入研究。在这里，我们总结了目前的知识的分类，特点和功能的主要浸润细胞，补体系统和外泌体在骨肉瘤免疫微环境。在每一节中，我们还强调了它们之间的复杂串扰网络以及相应的潜在治疗策略和临床应用，以加深我们对骨肉瘤的理解，并为即将有效的治疗提供参考，减少不良反应。
Osteosarcoma is a primary malignant tumor that tends to threaten children and adolescents, and the 5-year event-free survival rate has not improved significantly in the past three decades, bringing grief and economic burden to patients and society. To date, the genetic background and oncogenesis mechanisms of osteosarcoma remain unclear, impeding further research. The tumor immune microenvironment has become a recent research hot spot, providing novel but valuable insight into tumor heterogeneity and multifaceted mechanisms of tumor progression and metastasis. However, the immune microenvironment in osteosarcoma has been vigorously discussed, and the landscape of immune and non-immune component infiltration has been intensively investigated. Here, we summarize the current knowledge of the classification, features, and functions of the main infiltrating cells, complement system, and exosomes in the osteosarcoma immune microenvironment. In each section, we also highlight the complex crosstalk network among them and the corresponding potential therapeutic strategies and clinical applications to deepen our understanding of osteosarcoma and provide a reference for imminent effective therapies with reduced adverse effects.
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