Precisely printable and biocompatible silk fibroin bioink for digital light processing 3D printing.
Precisely printable and biocompatible silk fibroin bioink for digital light processing 3D printing.
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DOI：
10.1038/s41467-018-03759-y
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发表时间：
2018-04-24
影响因子：
16.6
通讯作者：
Park CH
中科院分区：
文献类型：
--
作者：
Kim SH;Yeon YK;Lee JM;Chao JR;Lee YJ;Seo YB;Sultan MT;Lee OJ;Lee JS;Yoon SI;Hong IS;Khang G;Lee SJ;Yoo JJ;Park CH
尽管三维（3D）生物打印技术在组织工程领域得到了广泛的关注，但仍然存在一些重大的工程挑战需要克服，包括缺乏具有生物相容性和可打印性的生物墨水。在这里，我们展示了一种由丝素蛋白（SF）创建的生物墨水，用于组织工程应用中的数字光处理（DLP）3D生物打印。在SF溶液的制备过程中，使用甲基丙烯酸缩水甘油酯（GMA）通过甲基丙烯酸酯化工艺制备SF基生物墨水（Sil-MA）。在实验测试中，Sil-MA水凝胶的机械和流变性能被证明是突出的，并且可以通过改变Sil-MA含量来调制。这种Sil-MA生物墨水使我们能够构建高度复杂的器官结构，包括心脏，血管，大脑，气管和耳朵，具有出色的结构稳定性和可靠的生物相容性。Sil-MA生物墨水非常适合用于DLP打印过程，并可根据特定的生物学要求应用于组织和器官工程。尽管3D生物打印技术在组织工程领域受到了广泛关注，但仍有一些重大挑战需要克服。在这里，作者介绍了具有可印刷性和生物相容性的丝素蛋白生物墨水，适用于数字光处理3D打印。
Although three-dimensional (3D) bioprinting technology has gained much attention in the field of tissue engineering, there are still several significant engineering challenges to overcome, including lack of bioink with biocompatibility and printability. Here, we show a bioink created from silk fibroin (SF) for digital light processing (DLP) 3D bioprinting in tissue engineering applications. The SF-based bioink (Sil-MA) was produced by a methacrylation process using glycidyl methacrylate (GMA) during the fabrication of SF solution. The mechanical and rheological properties of Sil-MA hydrogel proved to be outstanding in experimental testing and can be modulated by varying the Sil-MA contents. This Sil-MA bioink allowed us to build highly complex organ structures, including the heart, vessel, brain, trachea and ear with excellent structural stability and reliable biocompatibility. Sil-MA bioink is well-suited for use in DLP printing process and could be applied to tissue and organ engineering depending on the specific biological requirements. Although 3D bioprinting technology has gained much attention in the field of tissue engineering, there are still several significant challenges that need to be overcome. Here, the authors present silk fibroin bioink with printability and biocompatibility suited for digital light processing 3D printing.
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影响因子：
3.5
作者：
Kai, Dan;Prabhakaran, Molamma P.;Ramakrishna, Seeram
通讯作者：
Ramakrishna, Seeram
DOI：
10.1039/c5tb01468a
发表时间：
2015-11-14
期刊：
Journal of materials chemistry. B
影响因子：
--
作者：
Elomaa L;Pan CC;Shanjani Y;Malkovskiy A;Seppälä JV;Yang Y
通讯作者：
Yang Y
DOI：
10.1016/j.msec.2016.06.019
发表时间：
2016-11-01
影响因子：
7.9
作者：
Lee, Jung Min;Chae, Taesik;Park, Chan Hum
通讯作者：
Park, Chan Hum
DOI：
10.1080/00222340601044326
发表时间：
2007-01-01
影响因子：
1.4
作者：
Burtovyy, Oleksandr;Klep, Viktor;Luzinov, Igor
通讯作者：
Luzinov, Igor
影响因子：
4.8
作者：
Floren M;Migliaresi C;Motta A
通讯作者：
Motta A