The emerging role of long non-coding RNA in spinal cord injury.
The emerging role of long non-coding RNA in spinal cord injury.
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长链非编码RNA在脊髓损伤中的新作用
DOI：
10.1111/jcmm.13515
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发表时间：
2018-04
影响因子：
5.3
通讯作者：
Feng S
中科院分区：
文献类型：
--
作者：
Shi Z;Pan B;Feng S
脊髓损伤（SCI）是全球一项重大的健康负担，它会导致永久性神经功能缺损，每年大约有17000例新发病例。然而，由于对脊髓损伤的致病机制了解有限，目前没有有效的治疗方法能使功能恢复。近年来，长链非编码RNA（lncRNAs）在脊髓损伤中的生物学作用引起了世界各地研究人员的极大关注，越来越多的研究探讨了lncRNAs在脊髓损伤中的调控作用。在这篇综述中，我们总结了lncRNAs的生物发生、分类和功能，并重点关注了对lncRNAs参与脊髓损伤致病过程的研究，包括神经元丢失、星形胶质细胞增殖和活化、脱髓鞘、小胶质细胞活化、炎症反应和血管生成。这篇综述将有助于理解脊髓损伤的分子机制，并促进lncRNAs作为脊髓损伤治疗的诊断标志物和治疗靶点的潜在应用。
Spinal cord injury (SCI) is a significant health burden worldwide which causes permanent neurological deficits, and there are approximately 17,000 new cases each year. However, there are no effective and current treatments that lead to functional recovery because of the limited understanding of the pathogenic mechanism of SCI. In recent years, the biological roles of long non‐coding RNAs (lncRNAs) in SCI have attracted great attention from the researchers all over the world, and an increasing number of studies have investigated the regulatory roles of lncRNAs in SCI. In this review, we summarized the biogenesis, classification and function of lncRNAs and focused on the investigations on the roles of lncRNAs involved in the pathogenic processes of SCI, including neuronal loss, astrocyte proliferation and activation, demyelination, microglia activation, inflammatory reaction and angiogenesis. This review will help understand the molecular mechanisms of SCI and facilitate the potential use of lncRNAs as diagnostic markers and therapeutic targets for SCI treatment.
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影响因子：
6.8
作者：
Geng, Hua;Tan, Xiao-Di
通讯作者：
Tan, Xiao-Di
长链非编码 RNA 在癌症中的作用、功能和机制。
DOI：
10.1016/j.gpb.2015.09.006
发表时间：
2016-02
期刊：
Genomics, proteomics & bioinformatics
影响因子：
--
作者：
Fang Y;Fullwood MJ
通讯作者：
Fullwood MJ
影响因子：
64.5
作者：
Bhatt DM;Pandya-Jones A;Tong AJ;Barozzi I;Lissner MM;Natoli G;Black DL;Smale ST
通讯作者：
Smale ST
影响因子：
4
作者：
Chen, Xinlei;Liu, Lei;Zhang, Feng
通讯作者：
Zhang, Feng
影响因子：
5.2
作者：
Barriocanal M;Fortes P
通讯作者：
Fortes P