CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function.
CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function.
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DOI：
10.1084/jem.192.11.1553
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发表时间：
2000-12-04
期刊：
影响因子：
--
通讯作者：
Moser B
中科院分区：
文献类型：
--
作者：
Schaerli P;Willimann K;Lang AB;Lipp M;Loetscher P;Moser B
白细胞通过次级淋巴组织的运输受到趋化因子的精细调节。我们研究了以 CXC 趋化因子受体 5 (CXCR5) 表达为标志的人类 T 细胞亚群的功能特性。扁桃体中的记忆 T 细胞（而非幼稚 T 细胞）为 CXCR5+，并响应 B 细胞吸引趋化因子 1 (BCA-1) 进行迁移，该趋化因子由 B 细胞滤泡内的网状细胞和血管选择性表达。扁桃体 CXCR5+ T 细胞对次级淋巴组织中存在的其他趋化因子不产生反应，包括次级淋巴组织趋化因子 (SLC)、EBV 诱导的分子 1 配体趋化因子 (ELC) 和基质细胞衍生因子 1 (SDF-1)。扁桃体 CXCR5+ T 细胞位于 B 细胞滤泡的套膜和光区生发中心，并且伴随表达激活和共刺激标记物，包括 CD69、HLA-DR 和诱导共刺激物 (ICOS)，表明扁桃体 CXCR5+ T 细胞参与体液免疫反应。外周血 CXCR5+ T 细胞也属于 CD4+ 记忆 T 细胞亚群，但与扁桃体细胞相反，它们处于静息状态，并且向趋化因子迁移较弱。 CXCR5+ T 细胞产生细胞因子的效率非常低，但在与 B 细胞共培养期间可有效诱导抗体产生。这些特性将 CXCR5+ T 细胞描述为具有 B 细胞辅助功能的独特记忆 T 细胞子集，此处称为滤泡 B 辅助 T 细胞 (TFH)。
Leukocyte traffic through secondary lymphoid tissues is finely tuned by chemokines. We have studied the functional properties of a human T cell subset marked by the expression of CXC chemokine receptor 5 (CXCR5). Memory but not naive T cells from tonsils are CXCR5+ and migrate in response to the B cell–attracting chemokine 1 (BCA-1), which is selectively expressed by reticular cells and blood vessels within B cell follicles. Tonsillar CXCR5+ T cells do not respond to other chemokines present in secondary lymphoid tissues, including secondary lymphoid tissue chemokine (SLC), EBV-induced molecule 1 ligand chemokine (ELC), and stromal cell–derived factor 1 (SDF-1). The involvement of tonsillar CXCR5+ T cells in humoral immune responses is suggested by their localization in the mantle and light zone germinal centers of B cell follicles and by the concomitant expression of activation and costimulatory markers, including CD69, HLA-DR, and inducible costimulator (ICOS). Peripheral blood CXCR5+ T cells also belong to the CD4+ memory T cell subset but, in contrast to tonsillar cells, are in a resting state and migrate weakly to chemokines. CXCR5+ T cells are very inefficient in the production of cytokines but potently induce antibody production during coculture with B cells. These properties portray CXCR5+ T cells as a distinct memory T cell subset with B cell helper function, designated here as follicular B helper T cells (TFH).
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影响因子：
56.9
作者：
Campbell, JJ;Hedrick, J;Butcher, EC
通讯作者：
Butcher, EC
影响因子：
15.3
作者：
Bowman, E P;Campbell, J J;Soler, D;Dong, Z;Manlongat, N;Picarella, D;Hardy, R R;Butcher, E C
通讯作者：
Butcher, E C
影响因子：
56.9
作者：
Butcher, EC;Picker, LJ
通讯作者：
Picker, LJ
DOI：
10.1084/jem.184.2.569
发表时间：
1996-08-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Loetscher P;Seitz M;Baggiolini M;Moser B
通讯作者：
Moser B
影响因子：
15.9
作者：
Mazzucchelli, L;Blaser, A;Uguccioni, M
通讯作者：
Uguccioni, M