Changes in HPV16/18 Prevalence among Unvaccinated Women with Cervical Intraepithelial Neoplasia in Japan: Assessment of Herd Effects following the HPV Vaccination Program.
Changes in HPV16/18 Prevalence among Unvaccinated Women with Cervical Intraepithelial Neoplasia in Japan: Assessment of Herd Effects following the HPV Vaccination Program.
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DOI：
10.3390/vaccines10020188
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发表时间：
2022-01-25
期刊：
影响因子：
7.8
通讯作者：
For The Mint Study Group
中科院分区：
文献类型：
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作者：
Onuki M;Yamamoto K;Yahata H;Kanao H;Horie K;Konnai K;Nio A;Takehara K;Kamiura S;Tsuda N;Takei Y;Shigeta S;Nakai H;Yoshida H;Motohara T;Kato T;Nakamura K;Hamanishi J;Tasaka N;Ishikawa M;Kado N;Taira Y;Mori M;Iwata T;Takahashi F;Kukimoto I;Yoshikawa H;Yaegashi N;Matsumoto K;For The Mint Study Group
自2010年开始针对12-16岁日本女孩的人乳头瘤病毒（HPV）疫苗接种计划以来，1993年之前出生的女性接种率较低，但1994-1999年出生的女性接种率较高（约70%）。我们之前比较了接种疫苗和未接种疫苗队列之间1-3级宫颈上皮内瘤变（CIN 1 -3）或原位腺癌（AIS）中疫苗类型HPV 16和HPV 18的患病率，并在日本接种疫苗的女性中发现了直接的保护作用。在这项研究中，我们重点关注了CIN/AIS“未接种疫苗”队列中HPV 16/18患病率的变化。我们分析了2012-2021年期间新诊断为CIN/AIS的5051名年龄<40岁未接种疫苗的女性中HPV 16/18的患病率，以了解时间趋势。在<25岁的女性中，观察到9年来CIN 1（36.0- 10.0%，P趋势= 0.03）和CIN 2 -3/AIS（62.5- 36.4%，P趋势= 0.07）中HPV 16/18的患病率呈下降趋势。与1988-1993年出生队列相比，1994-1999年出生队列中20-24岁诊断的CIN 1和CIN 2 -3/AIS的HPV 16/18患病率较低（CIN 1为4.5% vs. 25.7%，CIN 2 -3/AIS为40.0% vs. 58.1%，均p = 0.04）。在未接种疫苗的CIN 1和CIN 2 -3/AIS年轻女性中，HPV 16/18患病率显著降低，表明日本HPV疫苗接种的群体效应。
Since the human papillomavirus (HPV) vaccination program for Japanese girls aged 12–16 years began in 2010, vaccination uptake has been low in women born before 1993 but high (approximately 70%) in those born during 1994–1999. We previously compared the prevalence of vaccine types HPV16 and HPV18 in cervical intraepithelial neoplasia grade 1–3 (CIN1–3) or adenocarcinoma in situ (AIS) between vaccinated and unvaccinated cohorts and found direct protection effects among vaccinated women in Japan. In this study, we focused on changes in HPV16/18 prevalence among “unvaccinated” cohorts with CIN/AIS. We analyzed HPV16/18 prevalence among 5051 unvaccinated women aged <40 years, newly diagnosed with CIN/AIS during 2012–2021 for time trends. Declining trends in HPV16/18 prevalence over 9 years were observed in CIN1 (36.0–10.0%, Ptrend = 0.03) and CIN2–3/AIS (62.5–36.4%, Ptrend = 0.07) among women aged <25 years. HPV16/18 prevalence in CIN1 and CIN2–3/AIS diagnosed at age 20–24 years was lower in 1994–1999 birth cohorts compared with 1988–1993 birth cohorts (4.5% vs. 25.7% for CIN1 and 40.0% vs. 58.1% for CIN2–3/AIS, both p = 0.04). Significant reduction in HPV16/18 prevalence among young unvaccinated women with CIN1 and CIN2–3/AIS suggests herd effects of HPV vaccination in Japan.
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DOI：
10.1093/cid/ciaa1770
发表时间：
2021-03-01
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Hoes J;Woestenberg PJ;Bogaards JA;King AJ;de Melker HE;Berkhof J;Hoebe CJPA;van der Sande MAB;van Benthem BHB;Medical Microbiological Laboratories and Public Health Services
通讯作者：
Medical Microbiological Laboratories and Public Health Services
影响因子：
1.6
作者：
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通讯作者：
Terada, Yukihiro
DOI：
10.1093/infdis/jix244
发表时间：
2017-09-01
期刊：
The Journal of infectious diseases
影响因子：
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作者：
Oliver SE;Unger ER;Lewis R;McDaniel D;Gargano JW;Steinau M;Markowitz LE
通讯作者：
Markowitz LE
影响因子：
5.7
作者：
Yagi A;Ueda Y;Nakagawa S;Masuda T;Miyatake T;Ikeda S;Abe H;Hirai K;Sekine M;Miyagi E;Enomoto T;Nakayama T;Kimura T
通讯作者：
Kimura T
影响因子：
6.4
作者：
Kudo, Risa;Yamaguchi, Manako;Enomoto, Takayuki
通讯作者：
Enomoto, Takayuki