Population Impact of Girls-Only Human Papillomavirus 16/18 Vaccination in The Netherlands: Cross-Protective and Second-Order Herd Effects.
Population Impact of Girls-Only Human Papillomavirus 16/18 Vaccination in The Netherlands: Cross-Protective and Second-Order Herd Effects.
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在荷兰仅女孩接种人乳头瘤病毒16/18疫苗的人群影响：交叉保护和二阶羊群效应。
DOI：
10.1093/cid/ciaa1770
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发表时间：
2021-03-01
期刊：
影响因子：
--
通讯作者：
Medical Microbiological Laboratories and Public Health Services
中科院分区：
文献类型：
--
作者：
Hoes J;Woestenberg PJ;Bogaards JA;King AJ;de Melker HE;Berkhof J;Hoebe CJPA;van der Sande MAB;van Benthem BHB;Medical Microbiological Laboratories and Public Health Services
人乳头瘤病毒(HPV)疫苗接种计划在人口层面产生重大影响，其影响超出了对接种疫苗个人的保护。我们评估了荷兰男性和女性接种HPV后长达8年的流行趋势，自2009年以来，荷兰一直向(未成年)女孩提供针对HPV16/18型的双价HPV疫苗接种，疫苗覆盖率中等。我们使用了PASSYON研究的数据，这是一项始于2009年的调查(预防接种)，每两年在16至24岁的性健康中心来访者中重复一次。我们使用泊松广义估计方程模型研究了2009至2017年间女性、异性恋男性和未接种疫苗的女性生殖器HPV阳性情况，并对个人和人群水平的混杂因素进行了调整。研究了SPF10-LiPA25平台检测到的25种HPV类型的趋势。共有6354名女性(64.7%自我报告未接种疫苗)和2414名异性恋男性纳入研究范围。观察到所有女性(每年12.6%[95%可信区间，10.6-14.5])、异性恋男性(每年13.0%[95%可信区间，8.3-17.5])和未接种疫苗的女性(每年5.4%[95%可信区间，2.9-7.8])的HPV-16/18疫苗类型百分比下降。我们观察到HPV-31(所有女性和异性恋男性)、HPV-45(所有女性)和所有高危HPV类型(所有女性和异性恋男性)显著下降。观察到HPV-56(所有妇女)和HPV-52(未接种疫苗的妇女)的感染显著增加。我们的结果为异性恋男性对HPV-16/18和交叉保护型的一级羊群效应提供了证据。此外，在未接种疫苗的妇女中，我们显示了针对疫苗类型的二级羊群效应。在一个疫苗接种率适中的国家，这些结果对于仅接种女孩的双价HPV疫苗的人口水平和临床影响是有希望的。这项研究介绍了自荷兰引入仅限女孩接种、疫苗接种量适中以来，人类乳头瘤病毒(HPV)阳性的趋势。我们发现，在异性恋男性和未接种疫苗的女性中，HPV-16/18疫苗类型的流行率正在下降，而在异性恋男性中，交叉保护型HPV-16/18疫苗的流行率正在下降。
Human papillomavirus (HPV) vaccination programs achieve substantial population-level impact, with effects extending beyond protection of vaccinated individuals. We assessed trends in HPV prevalence up to 8 years postvaccination among men and women in the Netherlands, where bivalent HPV vaccination, targeting HPV types 16/18, has been offered to (pre)adolescent girls since 2009 with moderate vaccination coverage. We used data from the PASSYON study, a survey initiated in 2009 (prevaccination) and repeated biennially among 16- to 24-year-old visitors of sexual health centers. We studied genital HPV positivity from 2009 to 2017 among women, heterosexual men, and unvaccinated women using Poisson generalized estimating equation models, adjusted for individual- and population-level confounders. Trends were studied for 25 HPV types detected by the SPF10-LiPA25 platform. A total of 6354 women (64.7% self-reported unvaccinated) and 2414 heterosexual men were included. Percentual declines in vaccine types HPV-16/18 were observed for all women (12.6% per year [95% confidence interval {CI}, 10.6–14.5]), heterosexual men (13.0% per year [95% CI, 8.3–17.5]), and unvaccinated women (5.4% per year [95% CI, 2.9–7.8]). We observed significant declines in HPV-31 (all women and heterosexual men), HPV-45 (all women), and in all high-risk HPV types pooled (all women and heterosexual men). Significant increases were observed for HPV-56 (all women) and HPV-52 (unvaccinated women). Our results provide evidence for first-order herd effects among heterosexual men against HPV-16/18 and cross-protective types. Additionally, we show second-order herd effects against vaccine types among unvaccinated women. These results are promising regarding population-level and clinical impact of girls-only bivalent HPV vaccination in a country with moderate vaccine uptake. This study presents trends in human papillomavirus (HPV) positivity since girls-only HPV vaccine introduction in the Netherlands, with moderate vaccine uptake. We show declining prevalences of vaccine types HPV-16/18 in heterosexual men and unvaccinated women, and of cross-protective types in heterosexual men.
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影响因子：
6.4
作者：
Baussano I;Lazzarato F;Ronco G;Franceschi S
通讯作者：
Franceschi S
影响因子：
6.4
作者：
de Martel C;Plummer M;Vignat J;Franceschi S
通讯作者：
Franceschi S
DOI：
10.1093/infdis/jix244
发表时间：
2017-09-01
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Oliver SE;Unger ER;Lewis R;McDaniel D;Gargano JW;Steinau M;Markowitz LE
通讯作者：
Markowitz LE
影响因子：
5.5
作者：
Woestenberg, Petra J.;van Benthem, Birgit H. B.;Hoebe, Christian J. P. A.
通讯作者：
Hoebe, Christian J. P. A.
影响因子：
11.8
作者：
Mesher, David;Soldan, Kate;Thomas, Sara L.
通讯作者：
Thomas, Sara L.