Antimicrobial and anti-biofilm activities of Lactobacillus kefiranofaciens DD2 against oral pathogens.
Antimicrobial and anti-biofilm activities of Lactobacillus kefiranofaciens DD2 against oral pathogens.
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DOI：
10.1080/20002297.2018.1472985
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发表时间：
2018
影响因子：
4.5
通讯作者：
Seo KH
中科院分区：
文献类型：
--
作者：
Jeong D;Kim DH;Song KY;Seo KH
背景：变形链球菌和远缘链球菌是龋病的主要致病菌。目的：研究乳酸杆菌（L. Kefiranofaciens DD2、DD5和DD6）分离自开菲尔和三种商业乳杆菌菌株（L. plantarum ATCC 10，012，L. johnsonii JCM 1022和L. rhamnosus ATCC 7469）作为潜在的口腔益生菌，它们在实验口腔环境中的存活性、抗微生物活性和抗S. mutans和S. sobrinus。结果如下：菌株DD2、ATCC 10012、ATCC 7469和JCM 1022具有最好的口服存活能力，包括耐氧性和酶抗性，并抑制S. mutans和S. sobrinus。特别是，DD2抑制了所有三类生物膜形成相关基因：与碳水化合物代谢相关的基因和编码调节生物膜和粘附蛋白的基因。结论：这些结果表明，新的开菲尔分离物L。开非诺霉素DD 2能有效地直接抑制S. mutans和S. sobrinus。
Background: Streptococcus mutans and Streptococcus sobrinus are major causative bacterial pathogens of dental caries. Objective: We investigated the applicability of three Lactobacillus strains (L. kefiranofaciens DD2, DD5, and DD6) isolated from kefir and three commercial Lactobacillus strains (L. plantarum ATCC 10,012, L. johnsonii JCM 1022, and L. rhamnosus ATCC 7469) as potential oral probiotics with respect to their survivability in an experimental oral environment, antimicrobial activity, and anti-biofilm formation activity against S. mutans and S. sobrinus. Results: Strains DD2, ATCC 10012, ATCC 7469, and JCM 1022 had the best oral survivability, including aerotolerance and enzymatic resistance, and inhibited the growth and biofilm formation of S. mutans and S. sobrinus. In particular, DD2 suppressed all three classes of biofilm formation-associated genes: those associated with carbohydrate metabolism and those encoding regulatory biofilm and adhesion proteins. Conclusions: These results indicate that the novel kefir isolate L. kefiranofaciens DD2 effectively and directly inhibits S. mutans and S. sobrinus.
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开菲尔对各种食品病原体和腐败细菌的抗菌活性。
影响因子：
--
作者：
Kim DH;Jeong D;Kim H;Kang IB;Chon JW;Song KY;Seo KH
通讯作者：
Seo KH
影响因子：
--
作者：
Farnaud SJ;Kosti O;Getting SJ;Renshaw D
通讯作者：
Renshaw D
影响因子：
6
作者：
Jeong, Dana;Kim, Dong-Hyeon;Seo, Kun-Ho
通讯作者：
Seo, Kun-Ho
影响因子：
2.7
作者：
Gaetti-Jardim, Ellen Cristina;Marqueti, Antonio Carlos;Gaetti-Jardim Junior, Elerson
通讯作者：
Gaetti-Jardim Junior, Elerson
影响因子：
3.4
作者：
Chuang, Li-Chuan;Huang, Chiung-Shing;Ou-Yang, Li-Wei;Lin, Shiao-Yu
通讯作者：
Lin, Shiao-Yu