Probiotic Lactobacillus paracasei effect on cariogenic bacterial flora.
Probiotic Lactobacillus paracasei effect on cariogenic bacterial flora.
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DOI：
10.1007/s00784-010-0423-9
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发表时间：
2011-08
影响因子：
3.4
通讯作者：
Lin, Shiao-Yu
中科院分区：
文献类型：
--
作者：
Chuang, Li-Chuan;Huang, Chiung-Shing;Ou-Yang, Li-Wei;Lin, Shiao-Yu
副干酪乳杆菌已被证明在体外抑制许多致病微生物如变形链球菌的生长。然而，其临床应用尚不清楚。在这里，我们研究了一种新的益生菌L。副干酪GMNL-33可以减少健康成年人与龋齿相关的唾液微生物数量。78名受试者（年龄20至26岁）完成了这项双盲、随机、安慰剂对照研究。益生菌/试验组（n = 42）和对照组（n = 36）取L. paracasei GMNL-33和安慰剂口服片剂，每天三次，分别持续2周。唾液S.分别在用药开始（T1）、结束（T2）和用药后2周（T3）用椅旁试剂盒测量变形杆菌、乳酸杆菌和唾液缓冲能力。结果未显示S计数的差异。在T1、T2和T3，益生菌组和对照组之间的变形杆菌和乳酸杆菌。然而，在益生菌组中，注意到了有趣的益生菌效应。在T1和T2之间，对S.观察到变形。然而，唾液中S。在T2和T3之间检测到变形杆菌（p = 0.016）。因此，可能需要通过口服给药途径给药2周。副干酪GMNL-33在益生菌作用中有效。
Lactobacillus paracasei has been demonstrated to inhibit the growth of many pathogenic microbes such as Streptococcus mutans, in vitro. However, its clinical application remains unclear. Here, we examined whether a novel probiotic L. paracasei GMNL-33 may reduce the caries-associated salivary microbial counts in healthy adults. Seventy-eight subjects (aged 20 to 26) had completed this double-blinded, randomized, placebo-controlled study. A probiotic/test (n = 42) and a control group (n = 36) took a L. paracasei GMNL-33 and a placebo oral tablet three times per day for 2 weeks, respectively. Bacterial counts of salivary S. mutans, lactobacilli, and salivary buffer capacity were measured with chair-side kits at the beginning (T1), the completion (T2) of medication, and 2 weeks after medication (T3). The results did not show differences in the counts of S. mutans and lactobacilli between probiotic and control groups at T1, T2, and T3. Nevertheless, within the probiotic group, an interesting probiotic effect was noticed. Between T1 and T2, no inhibitory effect against S. mutans was observed. However, a significant count reduction in the salivary S. mutans was detected between T2 and T3 (p = 0.016). Thus, a 2-week period of medication via oral administration route may be needed for L. paracasei GMNL-33 to be effective in the probiotic action.
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DOI：
10.1111/j.1365-263x.2007.00866.x
发表时间：
2008-01-01
影响因子：
3.8
作者：
Caglar, Esber;Kuscu, Ozgur Onder;Sandalli, Nuket
通讯作者：
Sandalli, Nuket
影响因子：
3.2
作者：
Montalto, M;Vastola, M;Gasbarrini, G
通讯作者：
Gasbarrini, G
影响因子：
1.9
作者：
MEURMAN, JH;ANTILA, H;SALMINEN, S
通讯作者：
SALMINEN, S
影响因子：
3.4
作者：
Caglar, E.;Kavaloglu, S. C.;Twetman, S.
通讯作者：
Twetman, S.
影响因子：
3
作者：
Ahola, AJ;Yli-Knuuttila, H;Korpela, R
通讯作者：
Korpela, R