The unstable bridge from stimulus processing to correct responding in Parkinson's disease
The unstable bridge from stimulus processing to correct responding in Parkinson's disease
复制标题
帕金森病从刺激处理到正确反应的不稳定桥梁
DOI：
10.1016/j.neuropsychologia.2013.09.017
复制
发表时间：
2013
期刊：
影响因子：
2.6
通讯作者：
Hamker F.H.
中科院分区：
文献类型：
--
作者：
Verleger R;Schroll H;Hamker F.H.
据推测，基底神经节实现了刺激(S)处理和运动反应(R)之间的联系。也有人提出，事件相关脑电电位的P3b分量是揭示S-R链接完整性的候选标记，其R-值通常与S锁定的试验平均值一样大。因此，P3复合波(由P3a和P3b组成)在时间锁定到S或按键R的试验中被测得平均值。预计在健康受试者的R锁定和S锁定的平均值中P3b相同大，但在R锁定的帕金森病(PD)患者(各12例)中P3b小于S锁定的平均值，这反映了PD中S-R链接的丢失。进一步假设，基底节从复杂的信号模式中提取明确的结果，从而解决相互竞争的反应之间的差异。如果是这样的话，到达帕金森病患者皮层的信号可能仍然不一致并产生冲突，就像错误负性(NE)类型的成分所表明的那样，即使帕金森氏病患者的反应正确。正如预期的那样，健康人具有相同的S和R锁定的P3b波幅和地形图，而PD患者在R锁定的P3b波幅小于S锁定的平均值。后一种结果是由于与R相关的额叶到中央的负向移动，在显性反应之前的最后100毫秒内与PD患者的P3b重叠。这种消极可能表明反应冲突，即使反应是正确的。与这一解释一致，PD患者在错误试验中不仅在R锁定的平均值中有NE类型的信号，就像健康受试者一样，而且在S锁定的平均值中也有NE类型的信号。这些发现支持了基底节的差异解决假说，并提示与S和R相关的NE类型成分的P3b重叠可能反映了帕金森病的一个主要病理生理特征。
It has been assumed that the basal ganglia implement links between stimulus (S) processing and motor response (R). It has also been proposed that the P3b component of the event-related EEG potential, which is usually as large in R- as in S-locked averages over trials, is a candidate marker to reveal integrity of S–R links. Therefore, the P3 complex (consisting of P3a and P3b) was here measured in averages over trials time-locked either to S or to the key-press R. P3b was expected to be equally large in healthy participants' R- and S-locked averages but to be smaller in R-locked than S-locked averages of patients with Parkinson's disease (PD) (n=12 each), reflecting the loss of S–R links in PD.It has been further assumed that the basal ganglia extract unambiguous results from complex signal patterns thereby resolving discrepancies between competing responses. If so, signals arriving at PD patients' cortex may still be discrepant and produce conflicts, as indicated by error-negativity (NE)-type components even with PD patients' correct responses.As expected, healthy persons had equal S- and R- locked P3b amplitudes and topographies, and PD patients had smaller P3b amplitudes in R-locked than S-locked averages. This latter result was due to an R-related fronto-central negative shift, overlapping PD patients' P3b in the final 100 ms before overt responding. This negativity might indicate response conflict even with correct responses. In line with this interpretation, PD patients had an NE-type signal in error trials not only in R-locked averages, like healthy participants, but in S-locked averages as well.These findings support the discrepancy-resolving hypothesis of the basal ganglia and suggest that the overlap of P3b by NE-type components, related both to S and R, may reflect a major pathophysiological feature in Parkinson's disease.
登录
查看更多内容
侧翼失误中与失误相关的消极性增强：失误预期还是失误重要性？
影响因子：
3.7
作者：
Di Pellegrino;Steinhauser
通讯作者：
Steinhauser
影响因子：
--
作者：
Tachibana, H;Aragane, K;Sugita, M
通讯作者：
Sugita, M
影响因子：
2.6
作者：
E. Seiss;P. Praamstra
通讯作者：
P. Praamstra
DOI：
10.1016/j.neunet.2011.10.008
发表时间：
2012-02
期刊：
Neural networks : the official journal of the International Neural Network Society
影响因子：
--
作者：
H. Schroll;Julien Vitay;F. Hamker
通讯作者：
H. Schroll;Julien Vitay;F. Hamker
西蒙任务期间帕金森病和与年龄相关的大脑振荡变化
影响因子：
1.7
作者：
C. Schmiedt;G. Schwendemann;M. Herrmann;C. Başar
通讯作者：
C. Başar