Sex differences in response to reduced nicotine content cigarettes.
Sex differences in response to reduced nicotine content cigarettes.
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对尼古丁含量降低的香烟的反应存在性别差异。
DOI：
10.1016/j.addbeh.2014.03.021
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发表时间：
2014
影响因子：
4.4
通讯作者：
Hatsukami,DorothyK
中科院分区：
文献类型：
--
作者：
Vogel,RachelIsaksson;Hertsgaard,LouiseA;Dermody,SarahS;Luo,Xianghua;Moua,Lor;Allen,Sharon;al'Absi,Mustafa;Hatsukami,DorothyK
背景当从普通品牌香烟转换时，极低尼古丁含量（VLNC）香烟导致吸烟数量、毒物暴露、戒断症状和依赖性的减少。一个相对未被探索的领域是什么因素可能会减轻VLNC香烟的影响。这项探索性分析的重点是VLNC香烟和尼古丁替代疗法的反应的性别差异。（58%女性，平均年龄47岁）比较a）0.05-0.09 mg尼古丁产量香烟; B）21 mg尼古丁贴片和3）具有21 mg尼古丁贴片的0.05-0.09尼古丁产量香烟进行。我们专注于产品使用的性别差异，以及产品对戒断反应的影响，从通常的品牌香烟和abstinence by randomized group.ResultsThe组合的VLNC香烟和尼古丁贴片是更有效地减少使用VLNC香烟和戒断症状的男性比女性，而女性同样响应VLNC香烟和没有尼古丁贴片。女性更有可能戒烟时，分配到任何的条件，将VLNC香烟比男性;然而，男性更有可能戒烟的尼古丁贴片单独的条件比females.ConclusionSex的吸烟者可能是一个重要的决定因素VLNC香烟和尼古丁贴片的影响。需要未来的大型随机试验来证实这些结果。
BackgroundWhen switching from usual brand cigarettes, very low nicotine content (VLNC) cigarettes lead to a reduction in the number of cigarettes smoked, toxicant exposure, withdrawal symptoms and dependence. One area that has been relatively unexplored is what factors might moderate the effects of VLNC cigarettes. This exploratory analysis focuses on sex differences in responses to VLNC cigarettes and nicotine replacement therapy.MethodsAn exploratory secondary analysis of a randomized trial of 235 participants (58% female, mean age 47 years) comparing a) 0.05–0.09 mg nicotine yield cigarettes; b) 21 mg nicotine patch and 3) 0.05–0.09 nicotine yield cigarettes with 21 mg nicotine patch was conducted. We focused on sex differences in product use, and impact of products on withdrawal response from usual brand cigarettes and abstinence by randomized group.ResultsThe combination of VLNC cigarettes and nicotine patch was more effective in reducing use of VLNC cigarettes and withdrawal symptoms among males than females, whereas females were equally responsive to VLNC cigarettes with and without the nicotine patch. Females were more likely to quit smoking than males when assigned to either of the conditions that incorporated the VLNC cigarettes; however, males were more likely to quit smoking in the nicotine patch alone condition than females.ConclusionSex of the smoker may be an important determinant for effects of VLNC cigarettes and nicotine patch. Future large randomized trials to confirm these results are needed.
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影响因子：
5.2
作者：
Hatsukami DK;Perkins KA;Lesage MG;Ashley DL;Henningfield JE;Benowitz NL;Backinger CL;Zeller M
通讯作者：
Zeller M
评估将尼古丁口香糖与自我指导行为治疗相结合以预防吸烟复吸的治疗方法。
影响因子：
5.9
作者：
Killen,JD;Fortmann,SP;Newman,B;Varady,A
通讯作者：
Varady,A
第 6 章 – 使用气相色谱和质谱技术测定尼古丁及其代谢物
影响因子：
--
作者：
P. Jacob;G. Byrd
通讯作者：
G. Byrd
视觉和嗅觉香烟烟雾刺激的主观和强化效应的性别差异。
DOI：
10.1080/14622200110043059
发表时间：
2001
期刊：
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.
影响因子：
--
作者：
Perkins,KA;Gerlach,D;Vender,J;Grobe,J;Meeker,J;Hutchison,S
通讯作者：
Hutchison,S
影响因子：
4.7
作者：
Becker, Karen M.;Rose, Jed E.;Albino, Anthony P.
通讯作者：
Albino, Anthony P.