Hormone use and risk for lung cancer: a pooled analysis from the International Lung Cancer Consortium (ILCCO).
Hormone use and risk for lung cancer: a pooled analysis from the International Lung Cancer Consortium (ILCCO).
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肺癌的激素使用和风险：国际肺癌财团（ILCCO）的合并分析。
DOI：
10.1038/bjc.2013.506
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发表时间：
2013-10-01
影响因子：
8.8
通讯作者：
Stucker, I.
中科院分区：
文献类型：
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作者：
Pesatori, A. C.;Carugno, M.;Consonni, D.;Hung, R. J.;Papadoupolos, A.;Landi, M. T.;Brenner, H.;Mueller, H.;Harris, C. C.;Duell, E. J.;Andrew, A. S.;McLaughlin, J. R.;Schwartz, A. G.;Wenzlaff, A. S.;Stucker, I.
口服避孕药（OC）的使用，激素替代疗法（HRT）和女性肺癌风险之间的关系仍有争议。我们对国际肺癌联盟的6项病例对照研究（1961例病例和2609例对照）进行了汇总分析。采用多变量非条件logistic回归和荟萃分析模型研究潜在的相关性。进行多项logistic回归以研究不同组织学类型的肺癌风险。OC（OR =0.81; 95%CI：0.68-0.97）和HRT使用者（OR=0.77; 95%CI：0.66-0.90）的肺癌风险降低。单用雌激素和雌激素+孕酮HRT均与风险降低相关（OR=0.76; 95%CI：0.61-0.94和OR=0.66; 95%CI：0.49-0.88）。未观察到与OC/HRT使用年限的剂量反应关系。OC使用者中鳞状细胞癌（OR=0.53; 95%CI：0.37-0.76）以及HRT使用者中腺癌（OR=0.79; 95%CI：0.66-0.95）和小细胞癌（OR=0.37; 95%CI：0.19-0.71）的风险降低最大。没有观察到与吸烟状况或BMI的相互作用。我们的研究结果表明，外源性激素可以在肺癌病因学中发挥保护作用。然而，由于与队列研究的流行病学证据不一致，需要进一步和更大规模的调查，以更全面地了解女性肺癌的发展。
The association between oral contraceptive (OC) use, hormone replacement therapy (HRT) and lung cancer risk in women is still debated. We performed a pooled analysis of six case–control studies (1961 cases and 2609 controls) contributing to the International Lung Cancer Consortium. Potential associations were investigated with multivariable unconditional logistic regression and meta-analytic models. Multinomial logistic regressions were performed to investigate lung cancer risk across histologic types. A reduced lung cancer risk was found for OC (odds ratio (OR)=0.81; 95% confidence interval (CI): 0.68–0.97) and HRT ever users (OR=0.77; 95% CI: 0.66–0.90). Both oestrogen only and oestrogen+progestin HRT were associated with decreased risk (OR=0.76; 95% CI: 0.61–0.94, and OR=0.66; 95% CI: 0.49–0.88, respectively). No dose-response relationship was observed with years of OC/HRT use. The greatest risk reduction was seen for squamous cell carcinoma (OR=0.53; 95% CI: 0.37–0.76) in OC users and in both adenocarcinoma (OR=0.79; 95% CI: 0.66–0.95) and small cell carcinoma (OR=0.37; 95% CI: 0.19–0.71) in HRT users. No interaction with smoking status or BMI was observed. Our findings suggest that exogenous hormones can play a protective role in lung cancer aetiology. However, given inconsistencies with epidemiological evidence from cohort studies, further and larger investigations are needed for a more comprehensive view of lung cancer development in women.
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影响因子：
13.6
作者：
Andersson, T;Alfredsson, L;Ahlbom, A
通讯作者：
Ahlbom, A
影响因子：
10.3
作者：
Chlebowski, Rowan T.;Anderson, Garnet L.;Stefanick, Marcia L.
通讯作者：
Stefanick, Marcia L.
影响因子：
3.6
作者：
Delaunay, F;Pettersson, K;Gustafsson, JÅ
通讯作者：
Gustafsson, JÅ
影响因子：
7.7
作者：
Kreuzer, M;Gerken, M;Wichmann, HE
通讯作者：
Wichmann, HE
DOI：
10.1080/00039890109604471
发表时间：
2001-07-01
期刊：
ARCHIVES OF ENVIRONMENTAL HEALTH
影响因子：
--
作者：
Hoffmann, K;Krause, C;Seifert, B
通讯作者：
Seifert, B