A review on the analytical procedures of halogenated flame retardants by gas chromatography coupled with single quadrupole mass spectrometry and their levels in human samples.
A review on the analytical procedures of halogenated flame retardants by gas chromatography coupled with single quadrupole mass spectrometry and their levels in human samples.
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DOI：
10.1016/j.envpol.2021.117476
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发表时间：
2021-09-15
期刊：
影响因子：
--
通讯作者：
Zhu J
中科院分区：
文献类型：
--
作者：
Martinez G;Niu J;Takser L;Bellenger JP;Zhu J
卤化阻燃剂（HFRs）市场不断发展，已经从广泛使用多溴联苯醚（PBDE）转向最近推出的混合物，如Firemaster 550， Firemaster 680, DP-25， DP-35和DP-515。这些替代品主要由非多溴二苯醚类HFRs组成，如2-乙基己基四溴苯甲酸酯（TBB）、二（2-乙基己基）四溴苯甲酸酯（TBPH）、1,2-二（2,4,6-三溴苯氧基）乙烷（BTBPE）和十溴二苯乙烷（DBDPE）。通常监测的其他HFRs包括decchlorane Plus （DP）、dec氯烷602 （Dec602）、dec氯烷603 （Dec603）、dec氯烷604 （Dec604）、5,6-二溴-1,10,11,12,13,13-六氯- 11-三环[8.2.1.02,9]三烷（HCDBCO）和4,5,6,7-四溴-1,1,3-三甲基-3-（2,3,4,5-四溴苯基）-2,3-二氢-1 -h -茚（OBTMPI）。本综述旨在重点介绍过去十年（2010-2020年）人类生物标本中HFRs的气相色谱-单四极杆质谱分析方法和人类标本中这些HFRs水平信息的综合进展。本综述中包括的人类标本包括血液、牛奶、粪便/胎便、头发和指甲。本综述总结了用于测量生物样品中HFRs的分析方法，包括提取和清理技术，这些方法主要采用了用于分析多溴二苯醚的方法。此外，本综述还讨论了包括多溴二苯醚和广泛的其他HFRs的分析中的新挑战。对人类样本中HFRs水平的审查表明，在许多情况下，多溴二苯醚仍然是最主要的HFRs，其次是DP。然而，在人类中也发现了新发的HFRs，尽管它们的发现频率和水平都低于多溴二苯醚和DP。本综述清楚地表明，在工业中工作或居住在工业区附近的人体内的HFR水平较高。回顾人类标本中出血热病毒浓度水平的分析方法和合成的最新进展
Halogenated flame retardants (HFRs) market is continuously evolving and have moved from the extensive use of polybrominated diphenyl ether (PBDE) to more recent introduced mixtures such as Firemaster 550, Firemaster 680, DP-25, DP-35, and DP-515. These substitutes are mainly composed of non-PBDEs HFRs such as 2-ethyl-hexyl tetrabromobenzoate (TBB), bis(2-ethylhexyl) tetrabromophthalate (TBPH), 1,2-bis-(2,4,6-tribromophenoxy) ethane (BTBPE) and decabromodiphenyl ethane (DBDPE). Other HFRs commonly being monitored include Dechlorane Plus (DP), Dechlorane 602 (Dec602), Dechlorane 603 (Dec603), Dechlorane 604 (Dec604), 5,6-dibromo-1,10,11,12,13,13-hexachloro- 11-tricyclo[8.2.1.02,9]tridecane (HCDBCO) and 4,5,6,7-tetrabromo-1,1,3-trimethyl-3-(2,3,4,5-tetrabromophenyl)-2,3-dihydro-1H-indene (OBTMPI). This review aims at highlighting the advances in the past decade (2010-2020) on both the analytical procedures of HFRs in human bio-specimens using gas chromatography coupled with single quadrupole mass spectrometry and synthesizing the information on the levels of these HFRs in human samples. Human specimen included in this review are blood, milk, stool/meconium, hair and nail. The review summarizes the analytical methods, including extraction and clean-up techniques, used for measuring HFRs in biological samples, which are largely adopted from those for analysing PBDEs. In addition, new challenges in the analysis to include both PBDEs and a wide range of other HFRs are also discussed in this review. Review of the levels of HFRs in human samples shows that PBDEs are still the most predominant HFRs in many cases, followed by DP. However, emerging HFRs are also being detected in human despite of the fact that both their detection frequencies and levels are lower than PBDEs and DP. It is clearly demonstrated in this review that people working in the industry or living close to the industrial areas have higher HFR levels in their bodies. Review of latest advances in analytical methods and synthesis of concentration levels of HFRs in human samples
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影响因子：
4.1
作者：
Björklund, J;Tollbäck, P;Östman, C
通讯作者：
Östman, C
影响因子：
11.8
作者：
Cequier, Enrique;Maria Marce, Rosa;Thomsen, Cathrine
通讯作者：
Thomsen, Cathrine
影响因子：
4.1
作者：
Cristale, Joyce;Lacorte, Silvia
通讯作者：
Lacorte, Silvia
DOI：
10.1080/03067319.2012.690150
发表时间：
2013-08-01
影响因子：
2.6
作者：
Bendig, Paul;Vetter, Walter
通讯作者：
Vetter, Walter
影响因子：
2.5
作者：
Carnevale, Amanda;Aleksa, Katarina;Koren, Gideon
通讯作者：
Koren, Gideon