Marburg virus infection detected in a common African bat.
Marburg virus infection detected in a common African bat.
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DOI：
10.1371/journal.pone.0000764
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发表时间：
2007-08-22
期刊：
影响因子：
3.7
通讯作者：
Leroy EM
中科院分区：
文献类型：
--
作者：
Towner JS;Pourrut X;Albariño CG;Nkogue CN;Bird BH;Grard G;Ksiazek TG;Gonzalez JP;Nichol ST;Leroy EM
马尔堡病毒和埃博拉病毒可在人类和类人猿中引起具有高病死率（80-90%）的大规模出血热（HF）暴发。鉴定这些病毒的自然宿主是该领域最重要的课题之一，也是了解其自然历史的基本关键。尽管这个病毒家族在近40年前就被发现了，但尽管进行了大量的生态研究，寻找这些致命病原体的天然储存库仍然是一个谜。在这里，我们报告发现马尔堡病毒在一种常见的果蝠（Rousettus aegyptiacus）在加蓬所示的发现病毒特异性RNA和IgG抗体在个别蝙蝠。这些马尔堡病毒阳性的蝙蝠代表了第一个自然感染的非灵长类动物。此外，这是非洲这一地区首次报告存在马尔堡病毒，从而扩大了该病毒的已知范围。这些数据表明，更多的地区面临MHF爆发的风险，而不是以前认识到的，并且与最近发表的一份报告相吻合，其中三种果蝠被证明可能是埃博拉病毒的宿主。
Marburg and Ebola viruses can cause large hemorrhagic fever (HF) outbreaks with high case fatality (80–90%) in human and great apes. Identification of the natural reservoir of these viruses is one of the most important topics in this field and a fundamental key to understanding their natural history. Despite the discovery of this virus family almost 40 years ago, the search for the natural reservoir of these lethal pathogens remains an enigma despite numerous ecological studies. Here, we report the discovery of Marburg virus in a common species of fruit bat (Rousettus aegyptiacus) in Gabon as shown by finding virus-specific RNA and IgG antibody in individual bats. These Marburg virus positive bats represent the first naturally infected non-primate animals identified. Furthermore, this is the first report of Marburg virus being present in this area of Africa, thus extending the known range of the virus. These data imply that more areas are at risk for MHF outbreaks than previously realized and correspond well with a recently published report in which three species of fruit bats were demonstrated to be likely reservoirs for Ebola virus.
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影响因子：
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