Bilateral fronto-parietal integrity in young chronic cigarette smokers: a diffusion tensor imaging study.
Bilateral fronto-parietal integrity in young chronic cigarette smokers: a diffusion tensor imaging study.
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年轻慢性吸烟者的双侧额顶叶完整性：弥散张量成像研究
DOI：
10.1371/journal.pone.0026460
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Hao W
中科院分区：
文献类型：
--
作者：
Liao Y;Tang J;Deng Q;Deng Y;Luo T;Wang X;Chen H;Liu T;Chen X;Brody AL;Hao W
背景在中国和其他国家，吸烟仍然是可预防的发病率和死亡率的主要原因。以前的研究已经证明了慢性吸烟者的灰质损失。然而，只有少数研究评估了该组白色物质完整性的变化。基于先前关于吸烟者白色物质完整性改变的报道，本研究的目的是在大量匹配良好的慢性吸烟者和非吸烟者样本中检查白色物质完整性的改变。方法学/主要发现使用体内扩散张量成像（DTI）测量44名慢性吸烟受试者（平均年龄28.0±5.6岁）和44名年龄和性别匹配的健康对照非吸烟志愿者（平均年龄26.3±5.8岁）的全脑白色物质完整性的差异。在3特斯拉西门子扫描仪（Allegra; Siemens Medical System）上进行DTI。数据显示，吸烟者有较高的分数各向异性（FA）比健康的非吸烟者在几乎对称的双边额顶叶束组成的一个主要的白色物质通路，上级纵束（SLF）。结论/意义我们发现几乎对称的双侧额顶叶白质的变化在一个相对较大的样本的慢性吸烟者。这些发现支持了长期吸烟涉及双侧额顶叶连接改变的假设。
Background Cigarette smoking continues to be the leading cause of preventable morbidity and mortality in China and other countries. Previous studies have demonstrated gray matter loss in chronic smokers. However, only a few studies assessed the changes of white matter integrity in this group. Based on those previous reports of alterations in white matter integrity in smokers, the aim of this study was to examine the alteration of white matter integrity in a large, well-matched sample of chronic smokers and non-smokers. Methodology/Principal Findings Using in vivo diffusion tensor imaging (DTI) to measure the differences of whole-brain white matter integrity between 44 chronic smoking subjects (mean age, 28.0±5.6 years) and 44 healthy age- and sex-matched comparison non-smoking volunteers (mean age, 26.3±5.8 years). DTI was performed on a 3-Tesla Siemens scanner (Allegra; Siemens Medical System). The data revealed that smokers had higher fractional anisotropy (FA) than healthy non-smokers in almost symmetrically bilateral fronto-parietal tracts consisting of a major white matter pathway, the superior longitudinal fasciculus (SLF). Conclusion/Significance We found the almost symmetrically bilateral fronto-parietal whiter matter changes in a relatively large sample of chronic smokers. These findings support the hypothesis that chronic cigarette smoking involves alterations of bilateral fronto-parietal connectivity.
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DOI：
10.1017/sl461145706007395
发表时间：
2007-12-01
影响因子：
4.8
作者：
Chung, Ain;Lyoo, In Kyoon;Renshaw, Perry F.
通讯作者：
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影响因子：
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影响因子：
3.4
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Ettenberg, Aaron
影响因子：
5.3
作者：
Hoeft, Fumiko;Barnea-Goraly, Naama;Reiss, Allan L.
通讯作者：
Reiss, Allan L.