Human immunodeficiency virus interaction with oral and genital mucosal epithelia may lead to epithelial-mesenchymal transition and sequestration of virions in the endosomal compartments.
Human immunodeficiency virus interaction with oral and genital mucosal epithelia may lead to epithelial-mesenchymal transition and sequestration of virions in the endosomal compartments.
复制标题
DOI：
10.1111/odi.13387
复制
发表时间：
2020-09
期刊：
影响因子：
3.8
通讯作者：
Tugizov SM
中科院分区：
文献类型：
--
作者：
Tugizov SM
口腔和生殖器粘膜上皮是多层上皮屏障，具有发达、紧密和粘连的连接。这些屏障是抵御包括人类免疫缺陷病毒(HIV)在内的许多病原体的第一道防线。然而，艾滋病毒与粘膜上皮细胞表面的相互作用可能激活转化生长因子-β(转化生长因子-β)和丝裂原激活的蛋白激酶信号通路。当这些通路被激活时，可能导致上皮连接的破坏和上皮-间充质转化(EMT)。艾滋病毒引起的粘膜屏障损伤可能会促进致病病毒、细菌、真菌和其他感染源的传播。HIV诱导的EMT促进高度运动/迁移的细胞。在口腔和生殖器粘膜中，如果EMT发生在人类乳头瘤病毒(HPV)感染的癌前或恶性细胞环境中，HPV相关的肿瘤过程可以通过促进恶性细胞的病毒入侵而加速。艾滋病毒还内化为口腔和生殖器粘膜上皮细胞。大多数(90%)内化的病毒粒子不会穿过上皮，而是滞留在内体隔室中数天。这些隔离的病毒粒子具有传染性。当与激活的外周血单核细胞和CD4+T淋巴细胞相互作用时，含有病毒的上皮细胞可以被转移。HIV-1释放的诱导和病毒从上皮细胞到淋巴细胞的细胞间传播是通过淋巴细胞受体功能相关抗原-1与上皮细胞受体细胞间黏附分子-1的相互作用而介导的。因此，粘膜上皮细胞可能是艾滋病毒的暂时性储存库，在病毒传播中可能发挥关键作用。
Oral and genital mucosal epithelia are multistratified epithelial barriers with well-developed tight and adherens junctions. These barriers serve as the first line of defense against many pathogens, including human immunodeficiency virus (HIV). HIV interaction with the surface of mucosal epithelial cells, however, may activate transforming growth factor-beta (TGF-β) and mitogen-activated protein kinase signaling pathways. When activated, these pathways may lead to the disruption of epithelial junctions and epithelial–mesenchymal transition (EMT). HIV-induced impairment of the mucosal barrier may facilitate the spread of pathogenic viral, bacterial, fungal, and other infectious agents. HIV-induced EMT promotes highly motile/migratory cells. In oral and genital mucosa, if EMT occurs within a human papillomavirus (HPV)-infected premalignant or malignant cell environment, the HPV-associated neoplastic process could be accelerated by promoting viral invasion of malignant cells. HIV also internalizes into oral and genital mucosal epithelial cells. The majority (90%) of internalized virions do not cross the epithelium, but are retained in endosomal compartments for several days. These sequestered virions are infectious. Upon interaction with activated peripheral blood mononuclear cells and CD4+ T lymphocytes, epithelial cells containing the virus can be transferred. The induction of HIV-1 release and the cell-to-cell spread of virus from epithelial cells to lymphocytes is mediated by interaction of lymphocyte receptor function-associated antigen-1 with the epithelial cell receptor intercellular adhesion molecule-1. Thus, mucosal epithelial cells may serve as a transient reservoir for HIV, which could play a critical role in viral transmission.
登录
查看更多内容
影响因子：
4.4
作者：
Callahan, MK;Popernack, PM;Henderson, AJ
通讯作者：
Henderson, AJ
DOI：
10.1073/pnas.85.3.900
发表时间：
1988-02-01
影响因子：
11.1
作者：
ALOIA, RC;JENSEN, FC;GORDON, LM
通讯作者：
GORDON, LM
影响因子：
4.8
作者：
Glauser, Dominique A.;Schlegel, Werner
通讯作者：
Schlegel, Werner
DOI：
10.1083/jcb.124.5.689
发表时间：
1994-03
期刊：
The Journal of cell biology
影响因子：
--
作者：
Hewlett LJ;Prescott AR;Watts C
通讯作者：
Watts C
影响因子：
5.4
作者：
Bobardt, Michael D.;Chatterji, Udayan;Gallay, Philippe A.
通讯作者：
Gallay, Philippe A.