The emerging relationship between the airway microbiota and chronic respiratory disease: clinical implications.
The emerging relationship between the airway microbiota and chronic respiratory disease: clinical implications.
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气道菌群与慢性呼吸道疾病之间的新兴关系：临床意义。
DOI：
10.1586/ers.11.76
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发表时间：
2011-12
影响因子：
3.9
通讯作者：
Lynch SV
中科院分区：
文献类型：
--
作者：
Huang YJ;Lynch SV
直到最近，特定微生物种的定殖或感染的证据与肺部疾病的发展、持续或恶化之间的关系已经告知了我们对气道微生物学的看法。然而，最近应用非培养物依赖性工具进行微生物组分析，发现慢性肺病患者气道中的微生物群比以前认识到的更多样化。新的证据表明，气道微生物群的组成在健康和疾病状态以及症状的严重程度方面有所不同，并且微生物群作为一个集体实体可能有助于与慢性气道疾病相关的病理生理过程。本文就哮喘、慢性阻塞性肺疾病和囊性纤维化的气道微生物学研究进展作一综述。基于来自传统微生物学方法和最近的非培养微生物组研究的证据，我们讨论了最近的研究结果对呼吸系统健康或疾病的潜在微生物决定因素的影响。
Until recently, relationships between evidence of colonization or infection by specific microbial species and the development, persistence or exacerbation of pulmonary disease have informed our opinions of airway microbiology. However, recent applications of culture-independent tools for microbiome profiling have revealed a more diverse microbiota than previously recognized in the airways of patients with chronic pulmonary disease. New evidence indicates that the composition of airway microbiota differs in states of health and disease and with severity of symptoms and that the microbiota, as a collective entity, may contribute to pathophysiologic processes associated with chronic airway disease. Here, we review the evolution of airway microbiology studies of chronic pulmonary disease, focusing on asthma, chronic obstructive pulmonary disease and cystic fibrosis. Building on evidence derived from traditional microbiological approaches and more recent culture-independent microbiome studies, we discuss the implications of recent findings on potential microbial determinants of respiratory health or disease.
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影响因子：
3.7
作者：
Erb-Downward JR;Thompson DL;Han MK;Freeman CM;McCloskey L;Schmidt LA;Young VB;Toews GB;Curtis JL;Sundaram B;Martinez FJ;Huffnagle GB
通讯作者：
Huffnagle GB
DOI：
10.1073/pnas.0608255104
发表时间：
2007-01-02
影响因子：
11.1
作者：
Brodie, Eoin L.;DeSantis, Todd Z.;Andersen, Gary L.
通讯作者：
Andersen, Gary L.
影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
5.4
作者：
Avadhanula, V;Rodriguez, CA;Adderson, EE
通讯作者：
Adderson, EE
影响因子：
158.5
作者：
Bisgaard, Hans;Hermansen, Mette Northman;Pipper, Christian Bressen
通讯作者：
Pipper, Christian Bressen