Injury-induced inhibition of small intestinal protein and nucleic acid synthesis.
Injury-induced inhibition of small intestinal protein and nucleic acid synthesis.
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损伤引起的小肠蛋白质和核酸合成抑制。
DOI：
10.1016/0016-5085(90)91074-g
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发表时间：
1990
期刊：
影响因子：
29.4
通讯作者：
Tompkins,RG
中科院分区：
文献类型：
--
作者：
Carter,EA;Hatz,RA;Yarmush,ML;Tompkins,RG
皮肤热损伤后早期小肠黏膜重量和营养吸收明显减少。由于这些肠道特性高度依赖于核酸和蛋白质的合成速率，因此我们测量了胸苷、尿苷和亮氨酸在体内融入小肠脱氧核糖核酸、核糖核酸和蛋白质的情况。空肠胸苷掺入量最低时，脱氧核糖核酸合成显著降低（p < 0.01）；这些发现被肠隐窝放射标记核的放射自显影鉴定所证实。蛋白合成在损伤后6 h降低（p < 0.01）， 48 h恢复正常，核糖核酸合成在损伤后18 h也降低（p < 0.01）。这些降低的脱氧核糖核酸、核糖核酸和蛋白质合成速率不太可能是缺血的结果，因为在其他关于这种损伤模型的研究中，肠道血流量并没有因烧伤而显著改变。引发急性炎症反应的因素可能直接抑制核酸和蛋白质的合成，导致损伤后营养吸收和肠道屏障功能的改变。
Small intestinal mucosal weight and nutrient absorption are significantly diminished early after cutaneous thermal injuries. Because these intestinal properties are highly dependent on rates of nucleic acid and protein synthesis, in vivo incorporation of thymidine, uridine, and leucine into small intestinal deoxyribonucleic acid, ribonucleic acid, and proteins were measured. Deoxyribonucleic acid synthesis was markedly decreased with the lowest thymidine incorporation in the jejunum (p < 0.01); these findings were confirmed by autoradiographic identification of radiolabeled nuclei in the intestinal crypts. Protein synthesis was decreased by 6 h postinjury (p < 0.01) but had returned to normal by 48 h. Consistent with a decreased rate of protein synthesis, ribonucleic acid synthesis was also decreased 18 h postinjury (p < 0.01). These decreased deoxyribonucleic acid, ribonucleic acid, and protein synthesis rates are not likely a result of ischemia because in other studies of this injury model, intestinal blood flow was not significantly changed by the burn injury. Potentially, factors initiating the acute inflammatory reaction may directly inhibit nucleic acid and protein synthesis and lead to alterations in nutrient absorption and intestinal barrier function after injury.
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放线菌酮对大鼠小肠隐窝细胞周期的影响
影响因子：
7.8
作者：
R. Verbin;E. Farber
通讯作者：
E. Farber
在 T 细胞介导的免疫受损的小鼠中，热损伤会促进细菌从胃肠道移位。
影响因子：
--
作者：
E. Deitch;J. Winterton;R. Berg
通讯作者：
R. Berg
烧伤应激促进小鼠胃肠道细菌的易位。
影响因子：
--
作者：
K. Maejima;E. Deitch;R. Berg
通讯作者：
R. Berg
DOI：
10.1097/00004630-198611000-00004
发表时间：
1986
期刊：
The Journal of burn care & rehabilitation
影响因子：
--
作者：
Carter,EA;Udall,JN;Kirkham,SE;Walker,WA
通讯作者：
Walker,WA
抑制蛋白质合成期间的脂肪吸收：淋巴乳糜微粒的研究。
影响因子：
15.9
作者：
R. Glickman;K. Kirsch;K. Isselbacher
通讯作者：
K. Isselbacher