Changes in the anterior cingulate cortex in Crohn's disease: A neuroimaging perspective.
Changes in the anterior cingulate cortex in Crohn's disease: A neuroimaging perspective.
复制标题
克罗恩病患者前扣带皮层的变化：神经影像学观点
DOI：
10.1002/brb3.2003
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发表时间：
2021-03
影响因子：
3.1
通讯作者：
Gao X
中科院分区：
文献类型：
--
作者：
Kong N;Gao C;Xu M;Gao X
有证据表明，克罗恩病 (CD) 的病理生理学不仅限于胃肠道，还与大脑密切相关。特别是前扣带皮层 (ACC)，作为默认模式网络 (DMN) 和疼痛矩阵的一部分，在第一大脑中发挥着不可或缺的作用，使用多种神经影像学模式显示异常。本综述总结了九项相关研究，这些研究使用结构磁共振成像、静息态功能磁共振成像和磁共振波谱研究了 ACC 的变化。从 1980 年到 2020 年 8 月，我们进行了广泛的 PubMed 文献检索。在对已确定文章的回顾中，特别关注分析方法、技术方案特征和 ACC 中的具体变化。在形态学方面，观察到灰质体积和皮质厚度减少，同时局部回旋指数增加。在功能方面，DMN内的功能连接（FC）得到了增加。 ACC 和杏仁核之间的 FC 减少。检测到较高振幅的低频波动和图论结果，包括连接强度、聚类系数和局部效率。在神经递质变化方面，谷氨酸浓度增加，γ-氨基丁酸减少，这为腹痛提供了合理的解释。这些变化可能归因于压力、疼痛和负面情绪，以及肠道微生物群的变化。对于 CD 患者，ACC 表现出结构、功能和代谢变化。就临床发现而言，ACC 在抑郁/焦虑和腹痛的发生中发挥着重要作用。因此，成功调节该途径可以指导治疗。本综述总结了使用结构磁共振成像（sMRI）、功能磁共振成像（fMRI）和磁共振波谱（MRS）研究 ACC 变化的相关研究。
Evidence suggests that Crohn's disease (CD) pathophysiology goes beyond the gastrointestinal tract and is also strongly associated with the brain. In particular, the anterior cingulate cortex (ACC), which plays an integral role in the first brain as part of the default mode network (DMN) and pain matrix, shows abnormalities using multiple neuroimaging modalities. This review summarizes nine related studies that investigated changes in the ACC using structural magnetic resonance imaging, resting‐state functional magnetic resonance imaging, and magnetic resonance spectroscopy. An extensive PubMed literature search was conducted from 1980 to August 2020. In a review of the articles identified, particular attention was paid to analysis methods, technical protocol characteristics, and specific changes in the ACC. In terms of morphology, a decrease in gray matter volume and cortical thickness was observed along with an increase in local gyrification index. In terms of function, functional connectivity (FC) within the DMN was increased. FC between the ACC and the amygdala was decreased. Higher amplitudes of low‐frequency fluctuation and graph theory results, including connectivity strength, clustering coefficient, and local efficiency, were detected. In terms of neurotransmitter changes, the concentrations of glutamate increased along with a decrease in gamma‐aminobutyric acid, providing a rational explanation for abdominal pain. These changes may be attributed to stress, pain, and negative emotions, as well as changes in gut microbiota. For patients with CD, the ACC demonstrates structural, functional, and metabolic changes. In terms of clinical findings, the ACC plays an important role in the onset of depression/anxiety and abdominal pain. Therefore, successful modulation of this pathway may guide treatment. This review has summarized related studies that investigated changes in the ACC in using structural magnetic resonance imaging (sMRI), functional magnetic resonance imaging (fMRI), and magnetic resonance spectrum (MRS).
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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