Profiling plasma peptides for the identification of potential ageing biomarkers in Chinese Han adults.
Profiling plasma peptides for the identification of potential ageing biomarkers in Chinese Han adults.
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分析血浆肽以鉴定中国汉族成年人潜在的衰老生物标志物
DOI：
10.1371/journal.pone.0039726
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Wang W
中科院分区：
文献类型：
--
作者：
Lu J;Huang Y;Wang Y;Li Y;Zhang Y;Wu J;Zhao F;Meng S;Yu X;Ma Q;Song M;Chang N;Bittles AH;Wang W
年龄增长与心血管疾病、糖尿病和癌症有关，并显示出显著的个体间差异。为了确定与衰老相关的生物标志物，我们对1890名中国汉族人进行了蛋白质组学分析，其中1136名男性和754名女性，年龄在18至82岁之间，使用基于弱阳离子交换磁珠的MALDI-TOF-MS分析。该研究确定了44种肽，这些肽在不同年龄组中的浓度不同。特别是，载脂蛋白A-I（ApoA 1）浓度在18至50岁之间逐渐增加，纤维蛋白原α（FGA）水平在同一年龄段内下降，而白蛋白（ALB）在中年个体中显著降低。此外，发现FGA和其他四种未鉴定蛋白质的血浆肽谱具有性别依赖性。血浆蛋白如FGA、ALB和ApoA 1与中国汉族人群的年龄显著相关，可作为年龄相关的生物标志物。
Advancing age is associated with cardiovascular disease, diabetes mellitus and cancer, and shows significant inter-individual variability. To identify ageing-related biomarkers we performed a proteomic analysis on 1890 Chinese Han individuals, 1136 males and 754 females, aged 18 to 82 years, using weak cation exchange magnetic bead based MALDI-TOF-MS analysis. The study identified 44 peptides which varied in concentration in different age groups. In particular, apolipoprotein A-I (ApoA1) concentration gradually increased between 18 to 50 years of age, the levels of fibrinogen alpha (FGA) decreased over the same age span, while albumin (ALB) was significantly degraded in middle-aged individuals. In addition, the plasma peptide profiles of FGA and four other unidentified proteins were found to be gender-dependent. Plasma proteins such as FGA, ALB and ApoA1 are significantly correlated with age in the Chinese Han population and could be employed as indicative ageing-related biomarkers.
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