The selective TAAR1 partial agonist RO5263397 promoted novelty recognition memory in mice.
The selective TAAR1 partial agonist RO5263397 promoted novelty recognition memory in mice.
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DOI：
10.1007/s00213-021-05937-1
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发表时间：
2021-11
影响因子：
3.4
通讯作者：
Li JX
中科院分区：
文献类型：
--
作者：
Wu R;Liu J;Seaman R Jr;Johnson B;Zhang Y;Li JX
痕量胺相关受体1（TAAR 1）是G蛋白偶联受体，其在调节多巴胺能、多巴胺能和多巴胺能传递中具有特定作用。TAAR 1激动剂已显示出促认知活性。然而，TAAR 1激动剂对记忆性能的影响在很大程度上仍然未知。在这里，通过使用小鼠新物体识别（NOR）测试，我们研究了选择性TAAR 1部分激动剂RO 5263397对识别记忆的影响。我们发现，RO 5263397显着增强检索短期记忆（STM;训练后20分钟）在雄性和雌性小鼠。RO 5263397促进野生型（WT）同窝小鼠而非TAAR 1-KO小鼠的STM恢复，表明RO 5263397的作用依赖于TAAR 1。有趣的是，与它们的WT窝相比，TAAR 1-KO小鼠显示出相似的STM水平，表明taar 1基因的遗传缺失不影响STM检索。此外，RO 5263397还促进了长期NOR记忆（训练后24小时）的检索。这些结果表明，TAAR 1激活促进NOR记忆提取。与先前的研究一致，我们的发现进一步表明TAAR 1激动剂具有促认知特性。
Trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor that has a particular role in regulating dopaminergic, serotonergic and glutamatergic transmission. TAAR1 agonists have shown pro-cognitive activities. However, it remains largely unknown of the effects of TAAR1 agonists on memory performance. Here, by using the mice novel object recognition (NOR) test, we examined the effects of the selective TAAR1 partial agonist RO5263397 on recognition memory. We found that RO5263397 significantly enhanced the retrieval of short-term memory (STM; 20 min after training) both in male and female mice. RO5263397 promoted the retrieval of STM in the wild-type (WT) littermates but not TAAR1-KO mice, indicating that the effects of RO5263397 was dependent on TAAR1. Interestingly, compared to their WT litters, TAAR1-KO mice showed similar levels of STM, suggesting that genetic deletion of taar1 gene did not affect the STM retrieval. Furthermore, RO5263397 also promoted the retrieval of long-term NOR memory (24 h after training). These results indicate that TAAR1 activation promotes NOR memory retrieval. Consistent with previous studies, our finding further suggests that TAAR1 agonists have pro-cognitive properties.
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DOI：
10.1080/13803395.2015.1132298
发表时间：
2016
影响因子：
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