Temporospatial study of the migration and distribution of cardiac neural crest in quail-chick chimeras.
Temporospatial study of the migration and distribution of cardiac neural crest in quail-chick chimeras.
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鹌鹑雏鸡嵌合体心脏神经嵴迁移和分布的时空研究。
DOI：
10.1002/aja.1001920109
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Kirby,ML
中科院分区：
文献类型：
--
作者：
Miyagawa-Tomita,S;Waldo,K;Tomita,H;Kirby,ML
心脏流出道的分隔是由心脏神经嵴形成的。在神经嵴从神经褶皱迁移之前消融神经嵴的该区域导致心脏和主动脉弓动脉的流出道和流入道的异常。本研究的目的是检查这些神经嵴细胞的迁移和分布，从咽弓到流出区的心脏在鸟类胚胎发育。将鹌鹑胚胎迁移前心脏神经嵴的每个区域植入鸡胚的相应区域，构建嵌合体。移植是在每一侧和两侧进行的。在Hamburger-汉密尔顿阶段18和25之间处死鹌鹑-小鸡嵌合体，并在连续石蜡切片中检查咽部区域和流出道，以确定每个阶段鹌鹑细胞的分布模式。神经嵴细胞来自推定弓3和4区域的神经轴分别占据主要咽弓3和4，虽然少数人群可以看到在咽弓2和6。神经嵴细胞从假定的弓6区域迁移，主要见于咽弓6，但他们也填充咽弓3和4。在第23期，在远端流出道发现了鹌鹑神经嵴细胞簇。
It has been demonstrated that the septation of the outflow tract of the heart is formed by the cardiac neural crest. Ablation of this region of the neural crest prior to its migration from the neural fold results in anomalies of the outflow and inflow tracts of the heart and the aortic arch arteries. The objective of this study was to examine the migration and distribution of these neural crest cells from the pharyngeal arches into the outflow region of the heart during avian embryonic development. Chimeras were constructed in which each region of the premigratory cardiac neural crest from quail embryos was implanted into the corresponding area in chick embryos. The transplantations were done unilaterally on each side and bilaterally. The quail‐chick chimeras were sacrificed between Hamburger‐Hamilton stages 18 and 25, and the pharyngeal region and outflow tract were examined in serial paraffin sections to determine the distribution pattern of quail cells at each stage. The neural crest cells derived from the presumptive arch 3 and 4 regions of the neuraxis occupied mainly pharyngeal arches 3 and 4 respectively, although minor populations could be seen in pharyngeal arches 2 and 6. The neural crest cells migrating from the presumptive arch 6 region were seen mainly in pharyngeal arch 6, but they also populated pharyngeal arches 3 and 4. Clusters of quail neural crest cells were found in the distal outflow tract at stage 23.
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禽胚胎中颅神经嵴细胞的分离和早期迁移。
影响因子：
2.7
作者：
Kathryn W. Tosney
通讯作者：
Kathryn W. Tosney
影响因子：
56.9
作者：
BOCKMAN, DE;KIRBY, ML
通讯作者：
KIRBY, ML
DOI：
--
发表时间：
1970
期刊：
Advances in Morphogenesis
影响因子：
--
作者：
J. A. Weston
通讯作者：
J. A. Weston
神经嵴消融对雏鸡心脏和弓动脉发育的影响。
DOI：
10.1002/aja.1001800403
发表时间：
1987
期刊：
The American journal of anatomy
影响因子：
--
作者：
Bockman,DE;Redmond,ME;Waldo,K;Davis,H;Kirby,ML
通讯作者：
Kirby,ML
影响因子：
2.7
作者：
D. Noden
通讯作者：
D. Noden