Cytochrome P450 (CYP2D6) genotype is associated with elevated systolic blood pressure in preterm infants after discharge from the neonatal intensive care unit.
Cytochrome P450 (CYP2D6) genotype is associated with elevated systolic blood pressure in preterm infants after discharge from the neonatal intensive care unit.
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DOI：
10.1016/j.jpeds.2011.01.002
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发表时间：
2011-07
影响因子：
5.1
通讯作者：
Murray, Jeffrey C.
中科院分区：
文献类型：
--
作者：
Dagle, John M.;Fisher, Tyler J.;Haynes, Susan E.;Berends, Susan K.;Brophy, Patrick D.;Morriss, Frank H., Jr.;Murray, Jeffrey C.
确定与早产儿出院后收缩压 (ESBP) 升高相关的遗传和临床危险因素。出院后对胎龄<32周的婴儿进行了方便队列随访；我们回顾性地确定了一个患有 ESBP 的受试者亚组（足月婴儿的 SBP > 90%）。基因检测发现了与 ESBP 相关的等位基因。以临床特征和基因型作为自变量，对 ESBP 结果进行多变量逻辑回归分析。 ESBP 的预测因子为：CYP2D6 (rs28360521) CC 基因型（OR 2.92；95% CI 1.48，5.79），根据门诊氧疗（OR 4.53，95% CI 2.23，8.81）和尿路感染史（OR 4.68，95% CI 1.47， 14.86）。通过多变量线性回归分析对最大 SBP 进行建模：最大 SBP = 84.8 mmHg + 6.8 mmHg（如果 CYP2D6 CC 基因型）+ 6.8 mmHg（如果出院补充氧气）+ 4.4 mmHg（如果接受住院糖皮质激素）（p = 0.0002）。 ESBP 在 NICU 出院后患有残余肺部疾病的早产儿中很常见。这项研究揭示了与 ESBP 相关的临床因素，确定了用于进一步测试的候选基因，并支持了对于足月婴儿的建议，即在 3 岁时监测血压的建议。
To determine genetic and clinical risk factors associated with elevated systolic blood pressure (ESBP) in preterm infants following discharge. A convenience cohort of infants <32 weeks gestational age was followed after discharge; we retrospectively identified a subgroup of subjects with ESBP (SBP > 90th percentile for term infants). Genetic testing identified alleles associated with ESBP. Multivariable logistic regression analysis was performed for the outcome ESBP with clinical characteristics and genotype as independent variables. Predictors of ESBP were: CYP2D6 (rs28360521) CC genotype (OR 2.92; 95% CI 1.48, 5.79), adjusted for outpatient oxygen therapy (OR 4.53, 95%CI 2.23, 8.81) and history of urinary tract infection (OR 4.68, 95% CI 1.47, 14.86). Maximum SBP was modeled by multivariable linear regression analysis: Maximum SBP = 84.8 mmHg + 6.8 mmHg (if CYP2D6 CC genotype) + 6.8 mmHg (if discharged on supplemental oxygen) + 4.4 mmHg (if received inpatient glucocorticoids) (p=0.0002). ESBP is common among preterm infants with residual lung disease following NICU discharge. This study reveals clinical factors associated with ESBP, identifies a candidate gene for further testing, and supports the recommendation that BP be monitored sooner than at age 3 years as suggested for term infants.
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影响因子：
5.2
作者：
Horvath, S;Xu, X;Laird, NM
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Laird, NM
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