Cannabis, tobacco and domestic fumes intake are associated with nasopharyngeal carcinoma in North Africa.
Cannabis, tobacco and domestic fumes intake are associated with nasopharyngeal carcinoma in North Africa.
复制标题
大麻、烟草和家庭烟雾的摄入与北非的鼻咽癌有关。
DOI：
10.1038/sj.bjc.6605281
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发表时间：
2009-10-06
影响因子：
8.8
通讯作者：
Corbex, M.
中科院分区：
文献类型：
--
作者：
Feng, B-J;Khyatti, M.;Ben-Ayoub, W.;Dahmoul, S.;Ayad, M.;Maachi, F.;Bedadra, W.;Abdoun, M.;Mesli, S.;Bakkali, H.;Jalbout, M.;Hamdi-Cherif, M.;Boualga, K.;Bouaouina, N.;Chouchane, L.;Benider, A.;Ben-Ayed, F.;Goldgar, D. E.;Corbex, M.
北非鼻咽癌（NPC）的生活方式危险因素尚不清楚。从2002年至2005年，我们采访了636例患者和615名对照，来自阿尔及利亚，摩洛哥和突尼斯，频率匹配的中心，年龄，性别和儿童家庭类型（城市/农村）。条件Logistic回归分析用于评估生活方式与鼻咽癌风险的关系，控制社会经济状况和饮食风险因素。吸烟和吸鼻烟（含添加剂的烟草粉末）摄入与分化型NPC显著相关，但与未分化癌（UCNT）无关，UCNT是这些人群中NPC的主要组织学类型。正如分层排列检验和条件Logistic回归所证明的那样，吸食大麻显著增加了NPC的风险，独立于吸烟，表明大麻和烟草之间的致癌机制不同。在儿童时期使用kanoun（紧凑型木炭炉）的家庭烹饪烟雾摄入增加了NPC风险，而成年期的暴露影响较小。酒精和水烟（水烟）都与风险无关。在北非西部，烟草、大麻和家庭烹饪烟雾的摄入是鼻咽癌的危险因素。
The lifestyle risk factors for nasopharyngeal carcinoma (NPC) in North Africa are not known. From 2002 to 2005, we interviewed 636 patients and 615 controls from Algeria, Morocco and Tunisia, frequency-matched by centre, age, sex, and childhood household type (urban/rural). Conditional logistic regression was used to evaluate the association of lifestyles with NPC risk, controlling for socioeconomic status and dietary risk factors. Cigarette smoking and snuff (tobacco powder with additives) intake were significantly associated with differentiated NPC but not with undifferentiated carcinoma (UCNT), which is the major histological type of NPC in these populations. As demonstrated by a stratified permutation test and by conditional logistic regression, marijuana smoking significantly elevated NPC risk independently of cigarette smoking, suggesting dissimilar carcinogenic mechanisms between cannabis and tobacco. Domestic cooking fumes intake by using kanoun (compact charcoal oven) during childhood increased NPC risk, whereas exposure during adulthood had less effect. Neither alcohol nor shisha (water pipe) was associated with risk. Tobacco, cannabis and domestic cooking fumes intake are risk factors for NPC in western North Africa.
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影响因子：
10.3
作者：
NING, JP;YU, MC;HENDERSON, BE
通讯作者：
HENDERSON, BE
影响因子：
3.3
作者：
Manichaikul, Ani;Palmer, Abraham A.;Broman, Karl W.
通讯作者：
Broman, Karl W.
影响因子：
7.7
作者：
Armstrong, RW;Imrey, PB;Sani, S
通讯作者：
Sani, S
影响因子：
6.4
作者：
YU, MC;GARABRANT, DH;HENDERSON, BE
通讯作者：
HENDERSON, BE
影响因子：
6.4
作者：
Feng, Bing-Jian;Jalbout, Majida;Corbex, Marilys
通讯作者：
Corbex, Marilys