Cognitive and neural signatures of the APOE E4 allele in mid-aged adults.
Cognitive and neural signatures of the APOE E4 allele in mid-aged adults.
复制标题
DOI：
10.1016/j.neurobiolaging.2014.01.145
复制
发表时间：
2014-07
影响因子：
4.2
通讯作者：
Rusted JM
中科院分区：
文献类型：
--
作者：
Evans S;Dowell NG;Tabet N;Tofts PS;King SL;Rusted JM
载脂蛋白E（APOE）e4等位基因与老年人认知障碍风险增加密切相关。在年轻人中也可能与增强的认知能力有关，APOE e4等位基因可能构成拮抗性多效性的一个例子。这项工作的目的是研究APOE e4等位基因在中年（45-55岁）期间的认知和神经（功能）影响，其中可能会向认知缺陷过渡。在持续性和内隐注意力以及前瞻性记忆的任务中，比较了APOE e4携带者（e4+）与非e4携带者（e4−），并采集了功能性磁共振成像数据。e4+在所有3项任务上的表现都相当于或优于e4-，尽管表现优势不如年轻人明显。在神经方面，e4+表现出较少的任务相关的外纹和顶叶区招聘。当将神经激活数据与在平行研究中获得的年轻成年人的数据进行比较时，这一点变得更加明显。正如预期的那样，中年参与者表现出更多的扩散性神经激活。值得注意的是，随着年龄的增长，e4+显示出相对无法招募顶叶区域。这是再加上一个倾向，显示更大的招聘额区，和激活不足的纹外视觉区。因此，中年e4+显示出一种通常在以后的生活中看到的神经募集模式，可能反映了描述e4基因型的加速老化特征的来源。
The apolipoprotein E (APOE) e4 allele is strongly associated with increased risk of cognitive impairments in older adulthood. There is also a possible link to enhanced cognitive performance in younger adults, and the APOE e4 allele may constitute an example of antagonistic pleiotropy. The aim of this work was to investigate the cognitive and neural (functional) effects of the APOE e4 allele during mid-age (45–55 years), where a transition toward cognitive deficit might be expected. APOE e4 carriers (e4+) were compared with non-e4 carriers (e4−) on tasks of sustained and covert attention and prospective memory, and functional magnetic resonance imaging data acquired. Performance by e4+ was equivalent or better than e4− on all 3 tasks, although performance benefits were less pronounced than in youth. Neurally, e4+ showed less task-related recruitment of extrastriate and parietal areas. This became more evident when neural activation data were compared with that of young adults acquired in a parallel study. As expected, mid-age participants showed more diffuse neural activation. Notable was the fact that e4+ showed a relative inability to recruit parietal regions as they aged. This was coupled with a tendency to show greater recruitment of frontal regions, and underactivation of extrastriate visual regions. Thus, mid-age e4+ show a pattern of neural recruitment usually seen later in life, possibly reflecting the source of an accelerated aging profile that describes the e4 genotype.
登录
查看更多内容
影响因子：
56.9
作者：
MAHLEY, RW
通讯作者：
MAHLEY, RW
影响因子：
16.2
作者：
Kim, Jungsu;Basak, Jacob M.;Holtzman, David M.
通讯作者：
Holtzman, David M.
DOI：
10.1016/j.jalz.2009.07.003
发表时间：
2010-07
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Dennis NA;Browndyke JN;Stokes J;Need A;Burke JR;Welsh-Bohmer KA;Cabeza R
通讯作者：
Cabeza R
影响因子：
3.7
作者：
Ewers, Michael;Insel, Philip;Weiner, Michael W.
通讯作者：
Weiner, Michael W.
影响因子：
2.6
作者：
Burgess, Paul W.;Gonen-Yaacovi, Gil;Volle, Emmanuelle
通讯作者：
Volle, Emmanuelle