ReviewIsoprostanes: Novel Bioactive Products of Lipid Peroxidation
ReviewIsoprostanes: Novel Bioactive Products of Lipid Peroxidation
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综述异前列烷：脂质过氧化的新型生物活性产物
作者：
S. Basu
异前列腺素是一类新型的前列腺素类化合物，由酯化多不饱和脂肪酸(PUFA)通过非酶自由基催化反应生物合成。这些化合物中有几个具有很强的生物活性，主要通过它们的肺和肾血管收缩作用来证明，并且半衰期很短。已有研究表明，异前列腺素通过血栓素受体作为完全或部分激动剂发挥作用。人类和实验研究都表明，异前列腺素与严重的炎症条件、缺血-再灌注、糖尿病和动脉粥样硬化有关。已有报道表明，F2-异前列腺素是可靠的脂质过氧化生物标志物，可在各种临床条件下作为体内氧化应激的潜在指示物，也可用于评价抗氧化剂或药物清除自由基的性能。F2-异前列腺素在正常妊娠组中的水平高于非妊娠组，但其生理作用迄今尚未得到很好的研究。由于生物活性的F2-异前列腺素在各种组织中不断形成，而且在正常的基础条件下，大量的这些有效化合物在尿液中以游离酸的形式未被代谢，个体间的差异很大，因此它们在调节正常生理功能中的作用可能具有进一步的生物学意义，但尚未披露。由于这些化合物在生理和病理条件下都存在于人和动物体内，可以作为可靠的脂质过氧化生物标志物，因此它们的强大生物活性引起了科学家的极大关注。
Isoprostanes, are a novel group of prostaglandin-like compounds that are biosynthesised from esterified polyunsaturated fatty acid (PUFA) through a non-enzymatic free radical-catalysed reaction. Several of these compounds possess potent biological activity, as evidenced mainly through their pulmonary and renal vasoconstrictive effects, and have short half-lives. It has been shown that isoprostanes act as full or partial agonists through thromboxane receptors. Both human and experimental studies have indicated associations of isoprostanes and severe inflammatory conditions, ischemia-reperfusion, diabetes and atherosclerosis. Reports have shown that F2-isoprostanes are authentic biomarkers of lipid peroxidation and can be used as potential in vivo indicators of oxidant stress in various clinical conditions, as well as in evaluations of antioxidants or drugs for their free radical-scavenging properties. Higher levels of F2-isoprostanes have been found in the normal human pregnancy compared to non-pregnancy, but their physiological role has not been well studied so far. Since bioactive F2-isoprostanes are continuously formed in various tissues and large amounts of these potent compounds are found unmetabolised in their free acid form in the urine in normal basal conditions with a wide inter-individual variation, their role in the regulation of normal physiological functions could be of further biological interest, but has yet to be disclosed. Their potent biological activity has attracted great attention among scientists, since these compounds are found in humans and animals in both physiological and pathological conditions and can be used as reliable biomarkers of lipid peroxidation.
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肝硬化中脂质过氧化增强。
DOI：
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发表时间：
1998
期刊：
Journal of investigative medicine : the official publication of the American Federation for Clinical Research.
影响因子：
--
作者：
Pratico,D;Iuliano,L;Basili,S;Ferro,D;Camastra,C;Cordova,C;FitzGerald,GA;Violi,F
通讯作者：
Violi,F
影响因子：
2.9
作者：
MORROW, JD;HARRIS, TM;ROBERTS, LJ
通讯作者：
ROBERTS, LJ
15-F2T 异前列烷-M（氧化应激的尿液生物标志物）的酶免疫分析。
影响因子：
--
作者：
Sasaki,DianeM;Yuan,Ying;Gikas,Katherine;Kanai,Kazuo;Taber,Douglass;Morrow,JasonD;Roberts2nd,LJackson;Callewaert,DenisM
通讯作者：
Callewaert,DenisM
影响因子：
5.8
作者：
Hoeldtke, RD;Bryner, KD;Hobbs, G
通讯作者：
Hobbs, G
影响因子：
4.2
作者：
AWAD, JA;MORROW, JD;BURK, RF
通讯作者：
BURK, RF