Epidemiology and secular trends of malignant lymphoma in Japan: Analysis of 9426 cases according to the World Health Organization classification.

Epidemiology and secular trends of malignant lymphoma in Japan: Analysis of 9426 cases according to the World Health Organization classification.
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DOI:
10.1002/cam4.1805
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发表时间:
2018-11
期刊:
影响因子:
4
通讯作者:
Ohshima K
Ohshima K
中科院分区:
医学3区
文献类型:
--
作者:
Muto R;Miyoshi H;Sato K;Furuta T;Muta H;Kawamoto K;Yanagida E;Yamada K;Ohshima K

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本研究概述了日本恶性淋巴瘤的流行病学和长期趋势。我们使用来自日本各地诊所和医院的数据,分析了2007 - 2014年诊断的9426例恶性淋巴瘤病例。我们发现,滤泡性淋巴瘤和甲氨蝶呤相关淋巴增生性疾病的比例在此期间增加,滤泡性淋巴瘤和弥漫性大B细胞淋巴瘤的发病年龄也增加。在男性和女性中均观察到滤泡性淋巴瘤和弥漫性大B细胞淋巴瘤的发病年龄显著增加(所有P值均<0.0001,女性中后一种疾病的P = 0.0448除外)。需要进一步的研究,以确定这些淋巴瘤的发病率和发病年龄较高的原因。此外,我们认为有必要继续观察这些趋势。
This study provides an overview of the epidemiology and secular trends of malignant lymphoma in Japan. Using data from clinics and hospitals throughout Japan, we analyzed 9426 cases of malignant lymphoma diagnosed in 2007‐2014. We show that the proportion of follicular lymphoma and methotrexate‐associated lymphoproliferative disorder increased during this time, as did the onset age for follicular lymphoma and diffuse large B‐cell lymphoma. Significant increases in onset age for follicular lymphoma and diffuse large B‐cell lymphoma were observed in both men and women (all P values <0.0001 except for P = 0.0448 for the latter disease in women). Further studies are required to determine the reasons for the higher proportion of and onset age for these lymphomas. Additionally, we believe that continued observation of these trends is necessary.
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