Subtype distribution of lymphomas in Southwest China: analysis of 6,382 cases using WHO classification in a single institution.
Subtype distribution of lymphomas in Southwest China: analysis of 6,382 cases using WHO classification in a single institution.
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中国西南地区淋巴瘤亚型分布：单一机构6382例WHO分类分析
DOI：
10.1186/1746-1596-6-77
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发表时间：
2011-08-22
影响因子：
2.6
通讯作者：
Liu WP
中科院分区：
文献类型：
--
作者：
Yang QP;Zhang WY;Yu JB;Zhao S;Xu H;Wang WY;Bi CF;Zuo Z;Wang XQ;Huang J;Dai L;Liu WP
根据世卫组织分类，分析了中国西南部淋巴肿瘤的亚型分布。这项研究旨在分析中国西南部淋巴瘤的亚型分布。
根据WHO分类，对中国西南部的一个机构进行了9年内诊断出9年内被诊断出的淋巴性肿瘤。
从2000年1月到2008年12月，建立了6,382例淋巴瘤患者的总数，其中成熟的B细胞肿瘤占56％，成熟的T-和NK细胞肿瘤占26％，并且前体淋巴结淋巴结肿瘤和霍奇金淋巴瘤前体。分别为5％和13％。混合细胞（76％）是经典霍奇金淋巴瘤的主要亚型。并且未观察到双峰年龄分布。 The top six subtypes of non-Hodgkin lymphoma were as follows: diffuse large B-cell lymphoma, extranodal NK/T-cell lymphoma, nasal type, extranodal marginal zone lymphoma of mucosa associated lymphoid tissue, follicular lymphoma, precursor lymphoid neoplasms, and chronic淋巴细胞白血病/小淋巴细胞淋巴瘤。大约一半的病例淋巴瘤，最频繁的涉及Waldeyer的环，胃肠道，鼻窦区域和皮肤。
西南中国的淋巴肿瘤表现出了一些流行病学特征，类似于西方和亚洲国家以及中国其他地区的文献中报道的特征，而某些亚型则显示出独特的特征。成熟的T/NK细胞肿瘤和外道淋巴瘤的高频率，尤其是对于鼻型NK/T细胞淋巴瘤，鼻类型是该系列最出色的特征。
BackgroundThe subtype distribution of lymphoid neoplasms in Southwest China was analyzed according to WHO classifications. This study aims to analyze subtype distribution of lymphomas in southwest China.MethodsLymphoid neoplasms diagnosed within 9 years in a single institution in Southwest China were analyzed according to the WHO classification.ResultsFrom January 2000 to December 2008, a total number of 6,382 patients with lymphoma were established, of which mature B-cell neoplasms accounted for 56%, mature T- and NK-cell neoplasms occupied 26%, and precursor lymphoid neoplasms and Hodgkin lymphomas were 5% and 13%, respectively. Mixed cellularity (76%) was the major subtype of classical Hodgkin lymphoma; and the bimodal age distribution was not observed. The top six subtypes of non-Hodgkin lymphoma were as follows: diffuse large B-cell lymphoma, extranodal NK/T-cell lymphoma, nasal type, extranodal marginal zone lymphoma of mucosa associated lymphoid tissue, follicular lymphoma, precursor lymphoid neoplasms, and chronic lymphocytic leukemia/small lymphocytic lymphoma. Extranodal lymphomas comprised about half of all cases, and most frequently involved Waldeyer's ring, gastrointestinal tract, sinonasal region and skin.ConclusionsThe lymphoid neoplasms of Southwest China displayed some epidemiologic features similar to those reported in literature from western and Asian countries, as well as other regions of China, whereas some subtypes showed distinct features. The high frequency of mature T/NK cell neoplasms and extranodal lymphomas, especially for extranodal NK/T-cell lymphoma, nasal type, is the most outstanding characteristic of this series.
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