Psychopathic traits modulate functional connectivity during pain perception and perspective-taking in female inmates.
Psychopathic traits modulate functional connectivity during pain perception and perspective-taking in female inmates.
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DOI：
10.1016/j.nicl.2022.102984
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Decety J
中科院分区：
文献类型：
--
作者：
Yoder KJ;Harenski CL;Kiehl KA;Decety J
PCL-R评分与女性囚犯的功能连接改变有关。PCL-R因子1和因子2子评分预测连接性的相反变化。在疼痛感知过程中，显着性网络中的功能连接发生了变化。社会认知网络中的连通性在观点采择过程中会发生改变。分享和理解他人痛苦的能力对于成功的社会交往至关重要，也是道德的基本基石。精神病是一种人格障碍，包括缺乏同情心和关心他人。在本研究中，功能磁共振成像被用来检查神经反应和功能连接与共情和情感的观点采择在女囚（N = 109）与不同水平的精神病特征，作为衡量与精神病检查表修订版（PCL-R）。参与者在痛苦或非痛苦的情况下观察手和脚，同时采用第一人称或第三人称视角。所有参与者在想象自我和想象他人阻滞期间，在观察疼痛时，前扣带回（aINS）、前扣带回（ACC）、颞顶交界区（TPJ）和辅助运动区（SMA）均表现出强大的神经反应。精神病态改变了显著性和社会认知网络核心节点的功能连接。感知描述躯体疼痛的刺激导致从右颞顶交界处到上级颞沟的功能耦合减少，这与PCL-R因子1（情感/人际）评分相关。与此相反，从右前叶到楔前叶的连接随着因子2（生活方式/反社会）评分的增加而增加。当采用第三人称视角时，精神病特征调制来自社会认知网络的连接，但不是显着网络，因子1分数与感觉运动皮层和颞极的连接增加相关，而因子2分数与ACC/SMA和额下回的连接减少相关。总的来说，这些结果表明，精神病患者的特质在监禁女性与非典型功能连接的显着性网络在疼痛共情处理和情感的观点采择在社会认知网络。
PCL-R scores are associated with altered functional connectivity in female inmates. PCL-R Factor 1 and Factor 2 subscores predicted opposite shifts in connectivity. Functional connectivity in the salience network is altered during pain perception. Connectivity in the social cognition network is altered during perspective-taking. The ability to share and understand the distress of others is critical for successful social interactions and is a fundamental building block of morality. Psychopathy is a personality disorder that includes lack of empathy and concern for others. In the present study, functional MRI was used to examine neural responses and functional connectivity associated with empathy and affective perspective-taking in female inmates (N = 109) with various levels of psychopathic traits, as measured with Psychopathy Checklist-Revised (PCL-R). Participants viewed hands and feet in painful or non-painful situations while adopting a first person or third person perspective. All participants demonstrated robust neural responses in anterior insula (aINS), anterior cingulate (ACC), temporoparietal junction (TPJ) and supplementary motor area (SMA) when viewing pain, both during imagine-self and imagine-other blocks. Psychopathy shifted the functional connectivity seeded in core nodes of the salience and social cognition networks. Perceiving stimuli depicting somatic pain led to decreased functional coupling from right temporoparietal junction to superior temporal sulcus, which correlated with scores on PCL-R Factor 1 (Affective/Interpersonal). In contrast, connectivity from right insula to precuneus increased with Factor 2 (Lifestyle/Antisocial) scores. When adopting a third-person perspective, psychopathic traits modulated connectivity from the social cognition network, but not the salience network, with Factor 1 scores associated with increased connectivity to sensorimotor cortex and temporal pole, while Factor 2 scores were associated with decreased connectivity with ACC/SMA and inferior frontal gyrus. Overall, these results demonstrate that psychopathic traits in incarcerated females are associated with atypical functional connectivity within the salience network during pain-empathy processing and within the social cognition network during affective perspective-taking.
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