Mindfulness-Based Cognitive Therapy Regulates Brain Connectivity in Patients With Late-Life Depression.
Mindfulness-Based Cognitive Therapy Regulates Brain Connectivity in Patients With Late-Life Depression.
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基于正念的认知疗法可调节晚年抑郁症患者的大脑连接。
DOI：
10.3389/fpsyt.2022.841461
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发表时间：
2022
影响因子：
4.7
通讯作者：
Sun X
中科院分区：
文献类型：
--
作者：
Li H;Yan W;Wang Q;Liu L;Lin X;Zhu X;Su S;Sun W;Sui M;Bao Y;Lu L;Deng J;Sun X
晚年抑郁症（LLD）是老龄化人口中一个重要的公共卫生问题。最近的研究发现，基于正念的认知疗法（MBCT）可以有效缓解重度抑郁症的抑郁症状。本研究探讨MBCT治疗LLD的临床效果及潜在的神经影像机制。我们招募了 60 名 LLD 参与者进行为期 8 周的随机对照试验 (ChiCTR1800017725)。患者被随机分为常规治疗 (TAU) 组或 MBCT+TAU 组。汉密尔顿抑郁量表（HAMD）和汉密尔顿焦虑量表（HAMA）用于评估症状。磁共振成像（MRI）用于测量静息态功能连接和结构连接的变化。我们还测量了大脑连接的变化与临床症状改善之间的关系。治疗 8 周后 (p < 0.001) 和 3 个月随访结束时 (p < 0.001)，MBCT+TAU 组的 HAMD 总评分显着低于 TAU 组。 MBCT+TAU 组中杏仁核和额中回 (MFG) 之间功能连接的增加与 HAMA 和 HAMD 评分的降低相关。弥散张量成像分析显示，治疗8周后，与TAU组相比，MBCT+TAU组的MFG-杏仁核各向异性分数显着增加。我们的研究表明 MBCT 可以改善与 LLD 相关的抑郁和焦虑症状。 MBCT 加强了杏仁核和 MFG 之间的功能和结构联系，这种沟通的增加与临床症状的改善相关。随机对照试验；后续研究；功能磁共振成像；大脑连接
Late-life depression (LLD) is an important public health problem among the aging population. Recent studies found that mindfulness-based cognitive therapy (MBCT) can effectively alleviate depressive symptoms in major depressive disorder. The present study explored the clinical effect and potential neuroimaging mechanism of MBCT in the treatment of LLD. We enrolled 60 participants with LLD in an 8-week, randomized, controlled trial (ChiCTR1800017725). Patients were randomized to the treatment-as-usual (TAU) group or a MBCT+TAU group. The Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA) were used to evaluate symptoms. Magnetic resonance imaging (MRI) was used to measure changes in resting-state functional connectivity and structural connectivity. We also measured the relationship between changes in brain connectivity and improvements in clinical symptoms. HAMD total scores in the MBCT+TAU group were significantly lower than in the TAU group after 8 weeks of treatment (p < 0.001) and at the end of the 3-month follow-up (p < 0.001). The increase in functional connections between the amygdala and middle frontal gyrus (MFG) correlated with decreases in HAMA and HAMD scores in the MBCT+TAU group. Diffusion tensor imaging analyses showed that fractional anisotropy of the MFG-amygdala significantly increased in the MBCT+TAU group after 8-week treatment compared with the TAU group. Our study suggested that MBCT improves depression and anxiety symptoms that are associated with LLD. MBCT strengthened functional and structural connections between the amygdala and MFG, and this increase in communication correlated with improvements in clinical symptoms. Randomized Controlled Trial; Follow-Up Study; fMRI; Brain Connectivity
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DOI：
10.1176/appi.ajp.2018.17060595
发表时间：
2018-08-01
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Han LKM;Aghajani M;Clark SL;Chan RF;Hattab MW;Shabalin AA;Zhao M;Kumar G;Xie LY;Jansen R;Milaneschi Y;Dean B;Aberg KA;van den Oord EJCG;Penninx BWJH
通讯作者：
Penninx BWJH
影响因子：
2.3
作者：
Lacerda, ALT;Nicoletti, MA;Soares, JC
通讯作者：
Soares, JC
DOI：
10.1097/jgp.0b013e318211069a
发表时间：
2011-09
期刊：
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
影响因子：
--
作者：
Burke J;McQuoid DR;Payne ME;Steffens DC;Krishnan RR;Taylor WD
通讯作者：
Taylor WD
影响因子：
25.8
作者：
Kaiser, Roselinde H.;Andrews-Hanna, Jessica R.;Wager, Tor D.;Pizzagalli, Diego A.
通讯作者：
Pizzagalli, Diego A.
DOI：
10.1016/j.jaac.2009.11.005
发表时间：
2010-02-01
影响因子：
13.3
作者：
Cullen, Kathryn R.;Klimes-Dougan, Bonnie;Lim, Kelvin O.
通讯作者：
Lim, Kelvin O.