Factors governing single-trial contextual fear conditioning in the weanling rat.
Factors governing single-trial contextual fear conditioning in the weanling rat.
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DOI：
10.1037/a0016733
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发表时间：
2009-10
影响因子：
1.9
通讯作者：
Stanton, M. E.
中科院分区：
文献类型：
--
作者：
Burman, M. A.;Murawski, N. J.;Schiffino, F. L.;Rosen, J. B.;Stanton, M. E.
虽然上下文的恐惧条件反射出现后，在发展中比外显线索恐惧条件反射，很少有人知道的刺激参数和生物基板所需的早期年龄。当前的实验采用了研究成年啮齿动物海马体功能的方法，以确定发育中大鼠背景恐惧条件反射的决定因素。实验1研究了断奶大鼠在出生后第23天（PND）所需的暴露时间，以证明上下文恐惧条件反射。这个实验表明，30 s的情境暴露足以支持条件反射。此外，预暴露增强条件反射立即足电击，上下文预暴露促进效应（CPFE），但没有影响上下文条件反射延迟休克。实验2表明，在暴露前NMDA受体失活损害PND 23的背景学习。因此，CPFE背后的共轭表征早在大鼠PND 23时就具有NMDA依赖性。
Although contextual fear conditioning emerges later in development than explicit-cue fear conditioning, little is known about the stimulus parameters and biological substrates required at early ages. The current experiments adapted methods for investigating hippocampus function in adult rodents to identify determinants of contextual fear conditioning in developing rats. Experiment 1 examined the duration of exposure required by weanling rats at postnatal day (PND) 23 to demonstrate contextual fear conditioning. This experiment demonstrated that 30 s of context exposure is sufficient to support conditioning. Furthermore, preexposure enhanced conditioning to an immediate footshock, the context preexposure facilitation effect (CPFE), but had no effect on contextual conditioning to a delayed shock. Experiment 2 demonstrated that NMDA receptor inactivation during preexposure impairs contextual learning at PND 23. Thus, the conjuctive representations underlying the CPFE are NMDA-dependent as early as PND23 in the rat.
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