Meta-analysis of serum C-reactive protein and cartilage oligomeric matrix protein levels as biomarkers for clinical knee osteoarthritis
Meta-analysis of serum C-reactive protein and cartilage oligomeric matrix protein levels as biomarkers for clinical knee osteoarthritis
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血清C反应蛋白和软骨寡聚基质蛋白水平作为临床膝骨关节炎生物标志物的荟萃分析
DOI：
10.1186/s12891-018-1932-y
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发表时间：
2018-01
影响因子：
2.3
通讯作者：
Zhang Junfeng
中科院分区：
文献类型：
--
作者：
Zhang Junfeng
背景C反应蛋白（CRP）和软骨寡聚基质蛋白（COMP）在膝骨关节炎（KOA）中的作用目前仍存在争议，本研究旨在探讨CRP和COMP与KOA发病/进展的关系。计算基于固定效应模型或随机效应模型的合并平均差（MD）及其95%置信区间（95% CI），以评估CRP和COMP在KOA发生或进展中的潜在作用。通过Cochran’s Q和I2检验评估异质性。当P <50%时< 0.05 or I2>，采用随机效应模型，当P <50%时，采用固定效应模型.同时分析CRP在不同程度疼痛中的作用。进行敏感性分析，以评估强度的荟萃analysis.ResultsFourteen研究纳入荟萃分析。基线CRP与KOA末次随访期CRP水平无差异（MD =-0.09，95%CI：-0.30，0.13）。汇总数据显示，与对照组相比，发生KOA的患者的CRP浓度较高（MD = 0.33，95% CI：0.04，0.63）。急性膝关节炎患者血清COMP水平明显高于急性膝关节炎患者（MD = 1.69，95% CI：0.61，2.76），疼痛程度最重的膝关节炎患者血清CRP水平明显高于急性膝关节炎患者（MD = 1.60，95% CI：0.52，2.67）。CRP和COMP浓度较高的患者发生KOA的可能性增加。然而，高CRP血清水平与KOA进展无关。此外，KOA患者疼痛程度越高，CRP浓度越高。
BackgroundThe roles of C-reactive protein (CRP) and cartilage oligomeric matrix protein (COMP) in knee osteoarthritis (KOA) remain controversial, thus the present study is aimed to explore the relationships between CRP, COMP, and the incidence/progression of KOA.MethodsA systematic search was conducted on PubMed and Embase until September, 2016 for all the relevant studies. The pooled mean difference (MD) with its 95% confidence interval (95% CI) based on fixed effects model or random effects model was calculated to assess the potential role of CRP and COMP in the incidence or progression of KOA. Heterogeneity was evaluated by Cochran’s Q and I2tests. WhenP< 0.05 or I2> 50%, a random effects model was chosen, otherwise, a fixed effects model was used. Moreover, the role of CRP in different degrees of pain was also analyzed. Sensitivity analysis was performed to evaluate the strength of the meta-analysis.ResultsFourteen studies were enrolled in the meta-analysis. No difference was found between baseline CRP and CRP levels in the last follow-up period of KOA (MD = − 0.09, 95% CI: -0.30, 0.13). Pooled data showed higher CRP concentration in patients with incident KOA when compared with controls (MD = 0.33, 95% CI: 0.04, 0.63). Moreover, higher serum COMP levels were found in patients with incident KOA (MD = 1.69, 95% CI: 0.61, 2.76) Additionally, significant higher CRP concentration was observed in KOA patients with highest degree of pain (MD = 1.60, 95% CI: 0.52, 2.67).ConclusionCRP and COMP serum levels were both associated with the incidence of KOA. Patients with a higher CRP and COMP concentration might have an increased probability of developing KOA. However, higher CRP serum levels was not related with KOA progression. Furthermore, KOA patients with more pain had higher CRP concentrations.
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影响因子：
2.9
作者：
Zhang Y;Zeng C;Wei J;Li H;Yang T;Yang Y;Deng ZH;Ding X;Lei G
通讯作者：
Lei G
DOI：
10.1136/bmj.b2535
发表时间：
2009-07-21
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
PRISMA Group
影响因子：
--
作者：
Zhang Q;Li H;Zhang Z;Yang F;Chen J
通讯作者：
Chen J
影响因子：
4.9
作者：
Sanchez-Ramirez DC;van der Leeden M;van der Esch M;Roorda LD;Verschueren S;van Dieën JH;Dekker J;Lems WF
通讯作者：
Lems WF
影响因子：
4
作者：
Lo CK;Mertz D;Loeb M
通讯作者：
Loeb M