Global dynamics of selective attention and its lapses in primary auditory cortex.
Global dynamics of selective attention and its lapses in primary auditory cortex.
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DOI：
10.1038/nn.4386
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发表时间：
2016-12
影响因子：
25
通讯作者：
O'Connell, Monica Noelle
中科院分区：
文献类型：
--
作者：
Lakatos, Peter;Barczak, Annamaria;Neymotin, Samuel A.;McGinnis, Tammy;Ross, Deborah;Javitt, Daniel C.;O'Connell, Monica Noelle
先前的研究表明，在选择性地关注外部世界的相关方面时，大脑通过将其神经元振荡与刺激的关键时间点或感觉器官的采样对齐来提取相关信息。这种对齐机制被称为振荡夹带。我们研究了非人类灵长类动物初级听觉皮层中这种机制的全球性、长时间尺度动态，并假设夹带的缺失与注意力的缺失相对应。通过检查电生理和行为的措施，我们观察到，除了缺乏夹带的外部刺激，注意力缺失的特点是高振幅α振荡，与α频率结构的神经元合奏和单个单元操作。引人注目的是，夹带和α振荡占主导地位的时期是强烈的反相关，并以超慢的速度有节奏地波动。我们的研究结果表明，这两种不同的大脑状态代表外部与内部导向的计算资源从事大规模的任务积极和任务消极的功能网络。
Previous research demonstrated that while selectively attending to relevant aspects of the external world, the brain extracts pertinent information by aligning its neuronal oscillations to key time points of stimuli or their sampling by sensory organs. This alignment mechanism is termed oscillatory entrainment. We investigated the global, long-timescale dynamics of this mechanism in the primary auditory cortex of nonhuman primates, and hypothesized that lapses of entrainment would correspond to lapses of attention. By examining electrophysiological and behavioral measures we observed that besides the lack of entrainment by external stimuli, attentional lapses were characterized by high amplitude alpha oscillations, with alpha frequency structuring of neuronal ensemble and single unit operations. Strikingly, entrainment and alpha oscillation dominated periods were strongly anti-correlated and fluctuated rhythmically at an ultra-slow rate. Our results indicate that these two distinct brain states represent externally versus internally oriented computational resources engaged by large-scale task-positive and task-negative functional networks.
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影响因子：
16.2
作者：
Fries P
通讯作者：
Fries P
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
DOI：
10.1073/pnas.0907658106
发表时间：
2010-01-05
影响因子：
11.1
作者：
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通讯作者：
Desimone, Robert
影响因子：
56.9
作者：
Buschman, Timothy J.;Miller, Earl K.
通讯作者：
Miller, Earl K.
DOI：
10.1073/pnas.1117190108
发表时间：
2011-11-29
影响因子：
11.1
作者：
Haegens, Saskia;Nacher, Veronica;Jensen, Ole
通讯作者：
Jensen, Ole