Matrix-Assisted Laser Desorption Ionization Time-of-Flight for Fungal Identification.

Matrix-Assisted Laser Desorption Ionization Time-of-Flight for Fungal Identification.
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矩阵辅助激光解吸电离飞机的真菌识别时间。

DOI:
10.1016/j.cll.2021.03.006
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发表时间:
2021-06
影响因子:
1.7
通讯作者:
Lau AF
Lau AF
中科院分区:
医学4区
文献类型:
--
作者:
Lau AF

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Many studies have shown successful performance of MALDI-TOF MS for rapid yeast and mold identification, yet very few laboratories have chosen to apply this technology into their routine clinical mycology workflow. Some of this hesitation may be attributable to the lack of standardization regarding culture methods, extraction methods, databases, and acquisition methods. This review will provide an overview of the current status of MALDI-TOF MS for fungal identification, including key findings in the literature, processing and database considerations, updates in technology, and exciting future prospects. Significant advances towards standardization have taken place over recent years; thus, accurate species level identification of yeasts and molds, particularly within species complexes and cryptic organisms, should be highly attainable, achievable, and practical in most clinical laboratories.
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