Human Milk-Based or Bovine Milk-Based Fortifiers Differentially Impact the Development of the Gut Microbiota of Preterm Infants.
Human Milk-Based or Bovine Milk-Based Fortifiers Differentially Impact the Development of the Gut Microbiota of Preterm Infants.
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DOI：
10.3389/fped.2021.719096
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发表时间：
2021
影响因子：
2.6
通讯作者：
Donovan SM
中科院分区：
文献类型：
--
作者：
Aguilar-Lopez M;Wetzel C;MacDonald A;Ho TTB;Donovan SM
背景：早产儿在新生儿重症监护病房（NICU）住院期间暴露于不同的饮食输入。这些包括人乳（HM），含有人乳（HMF）或牛乳（BMF）强化剂或配方奶粉。牛奶消费和强化类型会导致早产儿肠道微生物群结构的变化。本研究旨在根据喂养类型和人乳强化类型来表征PT婴儿的肠道微生物群及其与婴儿生长的可能关联。研究方法：97名出生时妊娠≤33周或<1，500 g的婴儿在出生后住院期间在NICU接受随访，直至出院。收集临床和饮食信息，包括分娩方式、妊娠并发症、机械通气、抗生素使用、体重、牛奶类型和摄入量。为了表征肠道微生物群组成，每周从研究参与者收集粪便样本。使用Illumina MiSeq技术对16 S rRNA细菌基因的V3-V4区域进行测序。结果如下：出生后，黑人母亲种族，校正胎龄（GA）和暴露于妊娠并发症，肠道微生物多样性和丰富的肠球菌，韦荣氏球菌，双歧杆菌，肠杆菌和拟杆菌有显着的影响。在住院期间，纠正GA和暴露于绒毛膜炎仍然对肠道微生物组成有影响。在早产儿的肠道微生物群中发现了两种不同的肠型。一种富含土卫二志贺菌，另一种富含未表征的肠杆菌科、克雷伯菌和狭义梭菌1。总体而言，HM和HMF强化是最常见的喂养策略。当食用BMF时，PT婴儿的生长速度高于食用HMF的婴儿。牛奶和强化类型与严格意义上的梭菌1，双歧杆菌和乳酸杆菌的丰度显着相关。结论：这项观察性研究显示，早产儿的粪便微生物群组成中，牛奶摄入量与暴露于HMF或BMF强化之间存在显著相关性。此外，这些结果显示了其他围产期因素对PT婴儿肠道微生物群的建立和发展的影响。
Background: Preterm infants are exposed to different dietary inputs during their hospitalization in the neonatal intensive care unit (NICU). These include human milk (HM), with a human milk-based (HMF) or a bovine milk-based (BMF) fortifier, or formula. Milk consumption and the type of fortification will cause changes in the gut microbiota structure of preterm infants. This study aimed to characterize the gut microbiota of PT infant according to the type of feeding and the type of HM fortification and its possible association with infant's growth. Methods: Ninety-seven infants born ≤33 wks of gestation or <1,500 g were followed during the hospitalization period in the NICU after birth until discharge. Clinical and dietary information was collected, including mode of delivery, pregnancy complications, mechanical ventilation, use of antibiotics, weight, and type and amount of milk consumed. To characterize the gut microbiota composition, weekly stool samples were collected from study participants. The V3–V4 region of the 16S rRNA bacterial gene was Sequenced using Illumina MiSeq technology. Results: After birth, black maternal race, corrected gestational age (GA) and exposure to pregnancy complications, had a significant effect on gut microbial diversity and the abundance of Enterococcus, Veillonella, Bifidobacterium, Enterobacter, and Bacteroides. Over the course of hospitalization, corrected GA and exposure to chorioamnionitis remained to have an effect on gut microbial composition. Two different enterotypes were found in the gut microbiota of preterm infants. One enriched in Escherichia-Shigella, and another enriched in uncharacterized Enterobacteriaceae, Klebsiella and Clostridium sensu stricto 1. Overall, HM and fortification with HMF were the most common feeding strategies. When consuming BMF, PT infants had higher growth rates than those consuming HMF. Milk and type of fortification were significantly associated with the abundance of Clostridium sensu stricto 1, Bifidobacterium and Lactobacillus. Conclusions: This observational study shows the significant association between milk consumption and the exposure to HMF or BMF fortification in the fecal microbiota composition of preterm infants. Additionally, these results show the effect of other perinatal factors in the establishment and development of PT infant's gut microbiota.
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影响因子：
5.2
作者：
Biagi E;Aceti A;Quercia S;Beghetti I;Rampelli S;Turroni S;Soverini M;Zambrini AV;Faldella G;Candela M;Corvaglia L;Brigidi P
通讯作者：
Brigidi P
影响因子：
3.6
作者：
KARLBERG, J;ALBERTSSONWIKLAND, K
通讯作者：
ALBERTSSONWIKLAND, K
影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
12.2
作者：
Aguilar-Lopez M;Dinsmoor AM;Ho TTB;Donovan SM
通讯作者：
Donovan SM
影响因子：
4.2
作者：
Allali I;Arnold JW;Roach J;Cadenas MB;Butz N;Hassan HM;Koci M;Ballou A;Mendoza M;Ali R;Azcarate-Peril MA
通讯作者：
Azcarate-Peril MA