Psychometrically matched tasks evaluating differential fMRI activation during form and motion processing.
Psychometrically matched tasks evaluating differential fMRI activation during form and motion processing.
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DOI：
10.1037/a0022984
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发表时间：
2011-09
期刊：
影响因子：
2.4
通讯作者：
Shekhar, Anantha
中科院分区：
文献类型：
--
作者：
Snyder, Andrea N.;Bockbrader, Marcie A.;Hoffa, Angela M.;Dzemidzic, Mario A.;Talavage, Thomas M.;Wong, Donald;Lowe, Mark J.;O'Donnell, Brian F.;Shekhar, Anantha
视觉感知和工作记忆的缺陷在神经精神疾病中很常见，并且已经通过功能性 MRI 进行了研究。然而，对大脑激活差异的解释可能与组间任务表现的差异相混淆。不同条件下任务难度的差异也可能在健康受试者的视觉处理研究中提出解释问题。为了解决这些问题，本研究对任务中的大脑激活进行了表征，这些任务在心理测量上与难度相匹配。功能磁共振成像 (fMRI) 用于评估 10 名健康受试者在静态和移动刺激的辨别和工作记忆判断过程中的大脑激活情况。对于所有任务条件，性能准确度匹配为 70.7%。与背侧流中的 V2 和 V5 相关的区域在运动处理任务期间被激活，而腹侧流中的 V4 在形状处理任务期间被激活。在工作记忆任务期间，与工作记忆相关的额顶叶区域也具有统计显着性。应用心理物理学方法来等同任务要求提供了一种实用的方法来等同功能磁共振成像研究中不同条件下的表现水平，并在可比的努力水平上比较健康组和认知障碍组。这些心理测量匹配的任务可以应用于患有各种认知障碍的患者，以研究多个先验定义的大脑区域的功能障碍。测量患有这些疾病的患者典型激活模式的变化可用于监测疾病进展、评估新药治疗，并可能用于开发早期诊断方法。
Deficits in visual perception and working memory are commonly observed in neuropsychiatric disorders and have been investigated using functional MRI. However, interpretation of differences in brain activation may be confounded with differences in task performance between groups. Differences in task difficulty across conditions may also pose interpretative issues in studies of visual processing in healthy subjects. In order to address these concerns, the present study characterized brain activation in tasks which were psychometrically matched for difficulty. Functional magnetic resonance imaging (fMRI) was used to assess brain activation in ten healthy subjects during discrimination and working memory judgments for static and moving stimuli. For all task conditions, performance accuracy was matched at 70.7%. Areas associated with V2 and V5 in the dorsal stream were activated during motion processing tasks and V4 in the ventral stream were activated during form processing tasks. Frontoparietal areas associated with working memory were also statistically significant during the working memory tasks. Application of psychophysical methods to equate task demands provides a practical method to equate performance levels across conditions in fMRI studies, and to compare healthy and cognitively impaired groups at comparable levels of effort. These psychometrically matched tasks can be applied to patients with a variety of cognitive disorders to investigate dysfunction of multiple a priori defined brain regions. Measuring the changes in typical activation patterns in patients with these diseases can be useful for monitoring disease progression, evaluating new drug treatments, and possibly for developing methods for early diagnosis.
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DOI：
10.1007/bf02274900
发表时间：
1996-02-01
影响因子：
4.7
作者：
Cuesta, MJ;Peralta, V;Juan, JA
通讯作者：
Juan, JA
影响因子：
2.9
作者：
Constantinidis, Christos;Procyk, Emmanuel
通讯作者：
Procyk, Emmanuel
影响因子：
4.6
作者：
Brenner, CA;Wilt, MA;O'Donnell, BF
通讯作者：
O'Donnell, BF
影响因子：
3.3
作者：
Curtis, CE
通讯作者：
Curtis, CE
影响因子：
9.9
作者：
Dieterich, M;Bucher, SF;Brandt, T
通讯作者：
Brandt, T