Plasma 25-hydroxyvitamin D during pregnancy and small-for-gestational age in black and white infants.
Plasma 25-hydroxyvitamin D during pregnancy and small-for-gestational age in black and white infants.
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DOI：
10.1016/j.annepidem.2012.04.015
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发表时间：
2012-08
影响因子：
5.6
通讯作者：
Gillman, Matthew W.
中科院分区：
文献类型：
--
作者：
Burris, Heather H.;Rifas-Shiman, Sheryl L.;Camargo, Carlos A., Jr.;Litonjua, Augusto A.;Huh, Susanna Y.;Rich-Edwards, Janet W.;Gillman, Matthew W.
关键词：
在一项前瞻性产前队列研究中，我们研究了妊娠中期和脐带血浆25-羟基维生素D （25[OH]D）与小胎龄（SGA）的关系，以及维生素D可能在多大程度上解释SGA的黑人/白人差异。我们研究了1067对白人和236对黑人母婴，他们来自马萨诸塞州8个产科办公室，都是怀孕早期的孕妇。我们使用免疫分析法分析25(OH)D水平，并使用多变量logistic模型来估计按25(OH)D水平分类的SGA的几率。妊娠中期平均（标准差[SD]） 25(OH)D水平为60 nmol/L，黑人（46 nmol/L[22]）低于白人（62 nmol/L[20]）。59例婴儿为SGA(4.5%)，黑人婴儿多于白人婴儿（8.5%对3.7%）。母亲25(OH)D水平<25 vs.≥25 nmol/L发生SGA的几率更高（调整优势比[OR] 3.17； 95%可信区间[CI]:1.16, 8.63）。在调整25(OH)D后，黑人与白人受试者中SGA的增加几率从2.04（1.04,4.04）降至1.68（0.82,3.46）。妊娠中期25(OH)D水平<25 nmol/L与SGA发生率增高相关。我们的数据提高了维生素D水平可能导致SGA种族差异的可能性。
In a prospective prenatal cohort study, we examined associations of second trimester and cord plasma 25-hydroxyvitamin D (25[OH]D) with small-for-gestational age (SGA), and the extent to which vitamin D might explain black/white differences in SGA. We studied 1067 white and 236 black mother-infant pairs recruited from 8 obstetrical offices early in pregnancy in Massachusetts. We analyzed 25(OH)D levels using an immunoassay and performed multivariable logistic models to estimate the odds of SGA by category of 25(OH)D level. Mean (standard deviation [SD]) second trimester 25(OH)D level was 60 nmol/L and was lower for black (46 nmol/L [22]) than white (62 nmol/L [20]) women. 59 infants were SGA (4.5%) and more black than white infants were SGA (8.5% vs. 3.7%). The odds of SGA were higher with maternal 25(OH)D levels <25 vs. ≥25 nmol/L (adjusted odds ratio [OR] 3.17; 95% confidence interval [CI]:1.16, 8.63). The increased odds of SGA among black vs. white participants decreased from an OR of 2.04(1.04, 4.04) to 1.68(0.82, 3.46) after adjusting for 25(OH)D. Second trimester 25(OH)D levels <25 nmol/L were associated with higher odds of SGA. Our data raise the possibility that Vitamin D status may contribute to racial disparities in SGA.
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影响因子：
4.7
作者：
Morley, R.;Carlin, J. B.;Ponsonby, A-L
通讯作者：
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MacFarlane, GD
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通讯作者：
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作者：
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