Lung cancer in the Swiss HIV Cohort Study: role of smoking, immunodeficiency and pulmonary infection.
Lung cancer in the Swiss HIV Cohort Study: role of smoking, immunodeficiency and pulmonary infection.
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DOI：
10.1038/bjc.2011.558
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发表时间：
2012-01-31
影响因子：
8.8
通讯作者：
Schoeni-Affolter, F.
中科院分区：
文献类型：
--
作者：
Clifford, G. M.;Lise, M.;Franceschi, S.;Egger, M.;Bouchardy, C.;Korol, D.;Levi, F.;Ess, S.;Jundt, G.;Wandeler, G.;Fehr, J.;Schmid, P.;Battegay, M.;Bernasconi, E.;Cavassini, M.;Calmy, A.;Keiser, O.;Schoeni-Affolter, F.
除了吸烟外，免疫缺陷和与艾滋病有关的肺部感染被认为是艾滋病毒感染者肺癌的独立原因。在瑞士艾滋病毒队列研究（SHCS）中或通过与瑞士癌症登记处（1985-2010）的联系，共确定了68例肺癌，并按中心、性别、艾滋病毒传播类别、年龄和日历期间分别与337例对照组相匹配。采用条件Logistic回归分析法估计比值比（OR）。总体而言，96.2%的肺癌患者和72.9%的对照组患者曾吸烟，证实了吸烟的高患病率及其与肺癌的强相关性（目前与从未吸烟的OR =14.4，95%置信区间（95% CI）：3.36-62.1）。无论是在1年内测量（<200 vs <500的OR =1.21，95%CI：0.49-2.96），还是在肺癌诊断前更早的时间，均未观察到CD 4+细胞计数与肺癌之间的显著相关性。联合抗逆转录病毒治疗与肺癌无显著相关性（OR =0.67，95% CI：0.29-1.52），AIDS病史伴（OR=0.49，95% CI：0.19-1.28）或不伴（OR=0.53，95% CI：0.24-1.18）肺部受累也无显著相关性。SHCS中的肺癌似乎与免疫缺陷或艾滋病相关的肺部疾病没有明确的相关性，但似乎可归因于大量吸烟。
Immunodeficiency and AIDS-related pulmonary infections have been suggested as independent causes of lung cancer among HIV-infected persons, in addition to smoking. A total of 68 lung cancers were identified in the Swiss HIV Cohort Study (SHCS) or through linkage with Swiss Cancer Registries (1985–2010), and were individually matched to 337 controls by centre, gender, HIV-transmission category, age and calendar period. Odds ratios (ORs) were estimated by conditional logistic regression. Overall, 96.2% of lung cancers and 72.9% of controls were ever smokers, confirming the high prevalence of smoking and its strong association with lung cancer (OR for current vs never=14.4, 95% confidence interval (95% CI): 3.36–62.1). No significant associations were observed between CD4+ cell count and lung cancer, neither when measured within 1 year (OR for <200 vs ⩾500=1.21, 95% CI: 0.49–2.96) nor further back in time, before lung cancer diagnosis. Combined antiretroviral therapy was not significantly associated with lung cancer (OR for ever vs never=0.67, 95% CI: 0.29–1.52), and nor was a history of AIDS with (OR=0.49, 95% CI: 0.19–1.28) or without (OR=0.53, 95% CI: 0.24–1.18) pulmonary involvement. Lung cancer in the SHCS does not seem to be clearly associated with immunodeficiency or AIDS-related pulmonary disease, but seems to be attributable to heavy smoking.
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影响因子：
3.8
作者：
Bower, M;Powles, T;Gazzard, B
通讯作者：
Gazzard, B
影响因子：
8.8
作者：
Dal Maso, L.;Polesel, J.;Franceschi, S.
通讯作者：
Franceschi, S.
影响因子：
11.8
作者：
Kirk, Gregory D.;Merlo, Christian;Engels, Eric A.
通讯作者：
Engels, Eric A.
HAART 早期和晚期癌症发病率的变化模式：瑞士 HIV 队列研究。
影响因子：
8.8
作者：
Franceschi, S.;Lise, M.;Clifford, G. M.;Rickenbach, M.;Levi, F.;Maspoli, M.;Bouchardy, C.;Dehler, S.;Jundt, G.;Ess, S.;Bordoni, A.;Konzelmann, I.;Frick, H.;Dal Maso, L.;Elzi, L.;Furrer, H.;Calmy, A.;Cavassini, M.;Ledergerber, B.;Keiser, O.
通讯作者：
Keiser, O.
DOI：
10.1093/jnci/djr003
发表时间：
2011-03-16
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Koshiol J;Rotunno M;Gillison ML;Van Doorn LJ;Chaturvedi AK;Tarantini L;Song H;Quint WG;Struijk L;Goldstein AM;Hildesheim A;Taylor PR;Wacholder S;Bertazzi PA;Landi MT;Caporaso NE
通讯作者：
Caporaso NE