Oxyhemoglobin Saturation Overshoot Following Obstructive Breathing Events Mitigates Sleep Apnea-Induced Glucose Elevations.
Oxyhemoglobin Saturation Overshoot Following Obstructive Breathing Events Mitigates Sleep Apnea-Induced Glucose Elevations.
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DOI：
10.3389/fendo.2018.00477
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发表时间：
2018
影响因子：
5.2
通讯作者：
Jun JC
中科院分区：
文献类型：
--
作者：
Pham LV;Schwartz AR;Jun JC
背景：阻塞性睡眠呼吸暂停（OSA）和夜间缺氧与血糖调节紊乱和糖尿病有关。阻塞性睡眠呼吸暂停、氧合谱和葡萄糖之间的时间关联尚未得到很好的描述。我们假设在呼吸暂停事件期间的血红蛋白氧饱和度和随后的呼吸暂停后饱和度超调预测夜间血糖。方法：在30例接受CPAP停药的OSA患者中，我们通过频率、去饱和深度和相对于基线的超调高度来描述SPO2波动。我们检查了前10分钟频繁取样的葡萄糖和SPO2波动之间的关系。我们开发了多变量混合效应线性回归，在控制OSA严重程度的同时，研究葡萄糖和SPO2波动水平之间的独立关联。结果：去饱和深度与血糖无相关性（p < 0.05）。相反，超调与葡萄糖呈剂量依赖性。每个SPO2峰值未上升到基线的1%以内，与葡萄糖升高0.49 mg/dL相关（p = 0.01），而超过基线的峰值为bb0.1 %，与葡萄糖降低0.46 mg/dL相关。调整平均SPO2和OSA严重程度后，超调仍然是血糖的独立预测因子（p < 0.05）。结论：呼吸暂停事件后SPO2的显著改善可以保护患者免受osa相关的血糖升高。
Background: Obstructive sleep apnea (OSA) and nocturnal hypoxia are associated with disturbances in glucose regulation and diabetes. Temporal associations between OSA, oxygenation profiles and glucose have not been well-described. We hypothesized that oxyhemoglobin desaturation during apneic events and subsequent post-apnea saturation overshoot predict nocturnal glucose. Methods: In 30 OSA patients who underwent polysomnography while subjected to CPAP withdrawal, we characterized SPO2 swings by frequency, desaturation depth, and overshoot height relative to baseline. We examined the associations between frequently sampled glucose and SPO2 swings during the preceding 10 min. We developed multi-variable mixed effects linear regression to examine the independent associations between glucose and each level of these SPO2 swings, while controlling for OSA severity. Results: Desaturation depth was not associated with glucose (p > 0.05). In contrast, overshoot was associated with glucose in a dose-dependent manner. Each SPO2 peak that did not rise to within 1% of baseline was associated with incremental glucose elevations of 0.49 mg/dL (p = 0.01), whereas peaks that exceeded baseline by >1% were associated with glucose reductions of 0.46 mg/dL. Overshoot remained an independent predictor of glucose after adjustment for mean SPO2 and OSA severity (p > 0.05). Conclusions: Vigorous SPO2 improvements after apneic events may protect patients against OSA-related glucose elevations.
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影响因子：
2.9
作者：
Okumiya K;Sakamoto R;Ishimoto Y;Kimura Y;Fukutomi E;Ishikawa M;Suwa K;Imai H;Chen W;Kato E;Nakatsuka M;Kasahara Y;Fujisawa M;Wada T;Wang H;Dai Q;Xu H;Qiao H;Ge RL;Norboo T;Tsering N;Kosaka Y;Nose M;Yamaguchi T;Tsukihara T;Ando K;Inamura T;Takeda S;Ishine M;Otsuka K;Matsubayashi K
通讯作者：
Matsubayashi K
影响因子：
158.5
作者：
YOUNG, T;PALTA, M;BADR, S
通讯作者：
BADR, S
影响因子：
3.3
作者：
FINDLEY, LJ;RIES, AL;WAGNER, PD
通讯作者：
WAGNER, PD
影响因子：
5
作者：
Punjabi, NM;Shahar, E;Resnick, HE
通讯作者：
Resnick, HE
DOI：
10.1183/13993003.01705-2016
发表时间：
2017-06
期刊：
The European respiratory journal
影响因子：
--
作者：
Pham LV;Miele CH;Schwartz NG;Arias RS;Rattner A;Gilman RH;Miranda JJ;Polotsky VY;Checkley W;Schwartz AR
通讯作者：
Schwartz AR