Social Cognition and Oxytocin in Huntington's Disease: New Insights.
Social Cognition and Oxytocin in Huntington's Disease: New Insights.
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亨廷顿氏病中的社会认知和催产素：新见解。
DOI：
10.3390/brainsci8090161
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发表时间：
2018-08-26
期刊：
影响因子：
3.3
通讯作者：
Ceravolo R
中科院分区：
文献类型：
--
作者：
Unti E;Mazzucchi S;Frosini D;Pagni C;Tognoni G;Palego L;Betti L;Miraglia F;Giannaccini G;Ceravolo R
本研究旨在将亨廷顿氏病（HD）患者的社会认知与血浆中的社会激素催产素（OT）水平联系起来。事实上，HD患者通常表现出社交能力下降，OT参与了结合行为和面部情绪识别的改善。12名轻度症状HD患者（II期Shoulson & Fahn）和11名性别/年龄匹配的对照（健康对照，HC），无并发精神疾病，在基线（T0）通过广泛的神经心理学测试对OT血浆水平和社会认知进行了研究。两年后（T1），12例患者中的8例也重新检查了社会认知。结果显示HD组与HC组相比T0-OT水平有降低趋势，平均值±标准差：6.5 ± 2.4 vs 9.9 ± 7.2 pg/mL，未达到统计学显著性。在T0时，患者在“Faux-Pas”和“Strange Stories”测试中的表现明显低于对照组（p < 0.05; p < 0.01）;还报告了视觉情感（p < 0.01）和言语刺激（p < 0.01）的感知降低，包括愤怒，恐惧和悲伤（p < 0.05; p < 0.01）。此外，在HD人群中，OT浓度与中性\假Pas测试中的T1表现呈正相关（p < 0.05），而认知蒙特利尔认知评估（莫卡）和简易精神状态检查（MMSE）评分与“奇怪故事”和Karolinska定向情绪面孔（KDEF）测试中的心理社会感知呈正相关（p < 0.05）。这项研究，尽管其局限性，支持OT和HD社会认知之间的相关性，这表明这种激素可能的治疗用途。应研究更多受试者和其他身体组织/体液，如脑脊液，以证实该假设。
This study is aimed at relating social cognition in Huntington’s Disease (HD) to plasma levels of the social hormone oxytocin (OT). Indeed, HD patients commonly display reduced social skills and OT is involved in bonding behavior and improved recognition of facial emotions. Twelve mild-symptomatic HD patients (stage II Shoulson & Fahn) and 11 gender/age matched controls (healthy controls, HC), without concurrent psychiatric disorders, were investigated at baseline (T0) for OT plasma levels and social cognition through an extensive battery of neuropsychological tests. Social cognition was also re-examined after two years (T1) in 8 of the 12 patients. Results showed a trend for reduced T0-OT levels in HD vs. HC, mean ± stardard deviation: 6.5 ± 2.4 vs. 9.9 ± 7.2 pg/mL, without reaching statistical significance. At T0, patients showed significantly lower performances than controls at the “Faux-Pas” and “Strange Stories” tests (p < 0.05; p < 0.01); a reduced perception of visual emotions (p < 0.01) and verbal stimuli (p < 0.01) was also reported, involving anger, fear, and sadness (p < 0.05; p < 0.01). Additionally, in the HD population, OT concentrations positively correlated with T1-performances at Neutral\Faux-Pas test (p < 0.05), whereas the cognitive Montreal Cognitive Assessment (MoCA) and Mini Mental State Examination (MMSE) scores positively correlated with psychosocial perception at the “Strange Stories” and Karolinska Directed Emotional Faces (KDEF) tests (p < 0.05). This study, despite its limitations, supports correlations between OT and HD social cognition, suggesting a possible therapeutic use of this hormone. More subjects and additional body tissues/fluids, such as cerebrospinal fluid, should be investigated to confirm this hypothesis.
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