Effect of aged garlic extract and s-allyl cysteine and their interaction with atenolol during isoproterenol induced myocardial toxicity in rats.
Effect of aged garlic extract and s-allyl cysteine and their interaction with atenolol during isoproterenol induced myocardial toxicity in rats.
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DOI：
10.4103/0253-7613.125185
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发表时间：
2014-01
影响因子：
2.4
通讯作者：
Asad M
中科院分区：
文献类型：
--
作者：
Avula PR;Asdaq SM;Asad M
本研究评价了老化大蒜提取物（AGE）及其组分S-烯丙基半胱氨酸（SAC）在异丙肾上腺素诱导的大鼠心脏毒性过程中的心脏保护作用及其与阿替洛尔的相互作用。以2 ml/kg或5 ml/kg的两种不同剂量口服给予大鼠AGE，而以13.1 mg/kg或32.76 mg/kg的剂量给予SAC。AGE或SAC单独给药或与阿替洛尔（6 mg/kg，p.o.）联合给药，隔日一次，持续3周。给药结束时，向大鼠给予两个剂量的异丙肾上腺素（150 mg/kg，s.c.）。记录心电图（ECG），然后抽血测定血清乳酸脱氢酶（LDH）和肌酐激酶-MB（CK-MB）活性。测定心肌组织匀浆（HTH）中LDH、CK-MB、超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和硫代巴比妥酸反应物质（TBARS）的活性。所有给药组的异丙肾上腺素诱导的ECG变化均恢复正常。AGE和SAC可引起血清LDH和CK-MB活性降低，而HTH则升高。阿替洛尔单独或与AGE和S-烯丙基半胱氨酸联合使用时，生物标志物活性表现出相似的变化。AGE具有剂量依赖性的心脏保护作用。然而，同时给予SAC和阿替洛尔（6 mg/kg，p.o）更有效地对抗异丙肾上腺素诱导的大鼠心脏毒性期间的心肌功能障碍。
The study evaluates the cardioprotective effect of aged garlic extract (AGE) and its constituent; S-allylcysteine (SAC) and their interaction with atenolol during isoproterenol induced cardiac toxicity in rats. Rats were administered AGE at two different doses of 2 ml/kg or 5 ml/kg orally whereas SAC was administered either at a dose 13.1 mg/kg or 32.76 mg/kg. The AGE or SAC was given alone or in combination with atenolol (6 mg/kg, p.o), every alternate day for three weeks. At the end of treatment, two doses of isoproterenol (150 mg/kg, s.c) were administered to rats. The electrocardiogram (ECG) was recorded followed by withdrawal of blood to estimate serum lactate dehydrogenase (LDH) and creatinine kinase-MB (CK-MB) activities. The activities of LDH, CK-MB as well as superoxide dismutase (SOD), catalase and thiobarbituric acid reactive substances (TBARS) were also determined in the heart tissue homogenate (HTH). The isoproterenol induced ECG changes were restored to normal in all treated groups. The AGE and SAC administration caused a decrease in serum LDH and CK-MB activities and an elevation of LDH and CK-MB activities in HTH. Atenolol alone or in combination with AGE and S-allylcsyteine demonstrated similar changes in biomarker activities. AGE showed dose-dependent cardioprotection. However, concurrent administration of SAC with atenolol (6 mg/kg, p.o) combated more effectively the myocardial dysfunction during isoproterenol induced cardiotoxicity in rats.
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影响因子：
4.5
作者：
Padmanabhan, M.;Prince, P. Stanely Mainzen
通讯作者：
Prince, P. Stanely Mainzen
影响因子：
4.2
作者：
Allison, GL;Lowe, GM;Rahman, K
通讯作者：
Rahman, K
影响因子：
3.2
作者：
Kebapcilar, Levent;Akinci, Baris;Yesil, Sena
通讯作者：
Yesil, Sena
影响因子：
3.9
作者：
LINK, EM
通讯作者：
LINK, EM
影响因子：
4.2
作者：
Rahman, K;Lowe, GM
通讯作者：
Lowe, GM