Construct and criterion validity of the Euro Qol-5D in patients with systemic lupus erythematosus.
Construct and criterion validity of the Euro Qol-5D in patients with systemic lupus erythematosus.
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Euro Qol-5D 在系统性红斑狼疮患者中的构建和标准有效性
DOI：
10.1371/journal.pone.0098883
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Lu LJ
中科院分区：
文献类型：
--
作者：
Wang SL;Wu B;Zhu LA;Leng L;Bucala R;Lu LJ
目的探讨可计算系统性红斑狼疮（SLE）患者质量调整生命年的欧洲五维生活质量量表（EQ-5D）的结构和效标效度。方法收集上海交通大学医学院附属仁济医院门诊随访的SLE患者。对EQ-5D与疾病特异性健康相关生活质量（HRQoL）、狼疮Qol、系统性红斑狼疮疾病活动指数（SLEDAI）指标、系统性狼疮国际合作诊所损伤指数（SDI）和患者特征等等效领域的横断面相关性进行了检验。评估区分不同疾病严重程度患者的能力的判别效度。还对上限和下限效应进行了评估。结果共纳入240例患者。除亲密关系（r = 0.25）和身体意象（r = 0.18）外，EQ-5D与LupusQoL的所有领域（r：0.44-0.7）中度至强相关。 EQ-5D与疾病的临床评估、SLEDAI（r =-0.589）和SDI（r =-0.509）之间存在中度负相关。 当与LupusQoL的等效领域相比时，EQ-5D具有良好的结构效度（r：0.631-0.812）。EQ-5D还可以区分不同疾病严重程度的患者（根据SLEDAI和SDI）。EQ-5D无下限效应，但上限效应仍然很强（34%）。结论EQ-5D在SLE患者中具有结构效度和效标效度。与HRQoL一起使用的疾病特异性指标可能是更好的选择。
Objective To investigate the construct and criterion validity of the Euro Qol-5D (EQ-5D), which allows quality-adjusted life-years to be calculated, in patients with systemic lupus erythematosus (SLE). Methods Consecutive SLE patients who had been followed at the Renji Hospital, School of Medicine, Shanghai Jiao Tong University were recruited. Cross-sectional correlations of the EQ-5D with equivalent domains in disease-specific health-related quality of life (HRQoL), LupusQol, Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) measures, the Systemic Lupus International Collaborating Clinics Damage Index (SDI), and patient characteristics were tested. Discriminant validity to assess the ability to distinguish between patients of different disease severity was assessed. There also were evaluations of ceiling and floor effects. Results 240 patients were recruited in total. The EQ-5D correlated moderately to strongly with all domains of the LupusQoL (r: 0.44–0.7) apart from intimate relationships (r = 0.25) and body image (r = 0.18). There was moderate negative correlation between EQ-5D and clinical assessment of disease, SLEDAI (r = −0.589) and SDI (r = −0.509). When compared with equivalent domains on LupusQoL, there was good construct validity in EQ-5D (r: 0.631–0.812). EQ-5D could also discriminate patients with varied disease severity (according SLEDAI and SDI). There was no floor effect in EQ-5D but the ceiling effect remains strong (34%). Conclusion Our results provide sufficient evidence that the EQ-5D displays construct and criterion validity for use in SLE patients. Disease-specific measures of HRQoL used alongside may be a better choice.
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影响因子：
3.7
作者：
Wang SL;Wu B;Leng L;Bucala R;Lu LJ
通讯作者：
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