Secondary data analysis investigating effects of marine omega-3 fatty acids on circulating levels of leptin and adiponectin in older adults.
Secondary data analysis investigating effects of marine omega-3 fatty acids on circulating levels of leptin and adiponectin in older adults.
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DOI：
10.1016/j.plefa.2021.102302
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发表时间：
2021-07
影响因子：
3
通讯作者：
McDaniel, J. C.
中科院分区：
文献类型：
--
作者：
Rausch, J. A.;Gillespie, S.;Orchard, T.;Tan, A.;McDaniel, J. C.
较高的瘦素和较低的脂联素水平与全身炎症和衰老疾病的进展有关。在患有肥胖和炎症的老年人中，我们量化了二十碳五烯酸 (EPA) 和二十二碳六烯酸 (DHA) 补充剂对瘦素、脂联素和瘦素与脂联素比率 (LAR) 的影响。我们还检查了脂肪因子和细胞因子水平之间的关联。采用随机、双盲、安慰剂对照设计，参与者（平均年龄 61.3 ± 2.1）每天接受 1.5 g EPA + 1.0 g DHA (n = 14) 或矿物油 (n = 18)。在所有研究时间间隔通过电化学发光对血浆脂肪因子和细胞因子水平进行定量。虽然没有检测到组间差异，但 EPA+DHA 组的 LAR 在第 4 周和第 8 周之间有所降低（降低了 23%，p=0.065）。脂联素水平与第 4 周时的 IL-1β 水平 (p=.02) 和第 8 周时的 TNF-α 水平 (p=.03) 呈负相关。补充 EPA+DHA 对老年人群的潜在益处值得进一步研究。
Higher leptin and lower adiponectin levels have been linked to progressing systemic inflammation and diseases of aging. Among older adults with obesity and an inflammatory conditions, we quantified effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementation on leptin, adiponectin, and the leptin-to-adiponectin ratio (LAR). We also examined associations among adipokine and cytokine levels. Using a randomized, double-blind, placebo-controlled design, participants (mean age 61.3 ± 2.1) received 1.5 g EPA + 1.0 g DHA (n = 14) or mineral oil (n = 18) daily. Plasma adipokine and cytokine levels were quantified by electrochemiluminescence at all study intervals. While no between-group differences were detected, there was a reduction in the LAR (by 23%, p=.065) between weeks 4 and 8 among the EPA+DHA group. Adiponectin levels were negatively associated with IL-1β levels at week 4 (p=.02) and TNF-α levels at week 8 (p=.03). Potential benefits of EPA+DHA supplementation among aging populations warrant further study.
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影响因子：
3.7
作者：
Everson-Rose SA;Clark CJ;Wang Q;Guo H;Mancuso P;Kravitz HM;Bromberger JT
通讯作者：
Bromberger JT
影响因子：
4.8
作者：
Ayina CNA;Endomba FTA;Mandengue SH;Noubiap JJN;Ngoa LSE;Boudou P;Gautier JF;Mbanya JC;Sobngwi E
通讯作者：
Sobngwi E
影响因子：
7.1
作者：
Allaire, Janie;Couture, Patrick;Lamarche, Benoit
通讯作者：
Lamarche, Benoit
影响因子：
8.2
作者：
Flachs, P;Mohamed-Ali, V;Kopecky, J
通讯作者：
Kopecky, J
DOI：
10.2174/1871530318666180131094733
发表时间：
2018-01-01
影响因子：
1.9
作者：
Borges, Maraisa D.;Franca, Eduardo L.;de Abreu, Luiz C.
通讯作者：
de Abreu, Luiz C.