Associations of 25 Hydroxyvitamin D and High Sensitivity C-reactive Protein Levels in Early Life.
Associations of 25 Hydroxyvitamin D and High Sensitivity C-reactive Protein Levels in Early Life.
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DOI：
10.3390/nu14010015
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发表时间：
2021-12-21
期刊：
影响因子：
5.9
通讯作者：
Chawes B
中科院分区：
文献类型：
--
作者：
Brustad N;Fink NR;Stokholm J;Bønnelykke K;Følsgaard NV;Hougaard D;Brix S;Lasky-Su J;Weiss ST;Chawes B
维生素 D 缺乏和高敏 C 反应蛋白 (hs-CRP) 升高与多种健康结果相关，但人们对早期生命轨迹以及 25 羟基维生素 D (25(OH)D) 和 hs-CRP 之间的关联缺乏了解。我们在两个丹麦母婴队列（COPSAC2010 和 COPSAC2000）中分别研究了从怀孕到儿童期以及整个儿童期的 25(OH)D 和 hs-CRP 纵向测量之间的关联。在 COPSAC2010 中，妊娠第 24 周和儿童 6 个月时 25(OH)D 浓度之间存在关联 (n = 633)：估计值 (95% CI)； 0.114 (0.041;0.187)，p = 0.002，6 个月至 6 岁时 25(OH)D 之间 (n = 475)：0.155 (0.083;0.228)，p < 0.001。这也在 COPSAC2000 队列中得到证实，脐带血中 25(OH)D 浓度和 4 岁时 (n = 188)：0.294 (0.127;0.461)，p < 0.001 以及 6 个月和 4 岁时 (n = 264)：0.260 (0.133;0.388)，p < 0.001。在 COPSAC2000 中，我们还发现儿童时期 6 个月和 12 岁时的 hs-CRP 之间存在关联 (n = 232)：0.183 (0.076;0.289)，p < 0.001。最后，我们在 COPSAC2010 中发现 6 个月大时 (n = 613) 25(OH)D 和 hs-CRP 的横截面测量值之间存在负相关：-0.004 (-0.008;-0.0004)，p = 0.030，但这在 COPSAC2000 中并未重复。在这项研究中，我们发现了从怀孕中期到婴儿期以及整个儿童时期 25(OH)D 浓度跨时间点之间存在关联的证据，以及儿童时期 hs-CRP 水平之间的关联，尽管相关性较弱。我们还在 COPSAC2010 中发现 25(OH)D 和 hs-CRP 浓度之间存在负横断面关联，表明维生素 D 在全身低度炎症中发挥作用，尽管这种关联在 COPSAC2000 中不存在。
Vitamin D deficiency and elevated high sensitivity C-reactive protein (hs-CRP) have been associated with several health outcomes, but knowledge on early life trajectories and association between 25 hydroxyvitamin D (25(OH)D) and hs-CRP is lacking. We investigated the association between longitudinal measurements of 25(OH)D and hs-CRP, respectively, from pregnancy to childhood and throughout childhood in two Danish mother–child cohorts—the COPSAC2010 and COPSAC2000. In COPSAC2010, there was an association between 25(OH)D concentrations at week 24 in pregnancy and at age 6 months in childhood (n = 633): estimate (95% CI); 0.114 (0.041;0.187), p = 0.002, and between 25(OH)D at age 6 months and 6 years (n = 475): 0.155 (0.083;0.228), p < 0.001. This was also demonstrated in the COPSAC2000 cohort between 25(OH)D concentrations in cord blood and at age 4 years (n = 188): 0.294 (0.127;0.461), p < 0.001 and at age 6 months and 4 years (n = 264): 0.260 (0.133;0.388), p < 0.001. In COPSAC2000, we also found an association between hs-CRP at age 6 months and 12 years in childhood (n = 232): 0.183 (0.076;0.289), p < 0.001. Finally, we found a negative association between the cross-sectional measurements of 25(OH)D and hs-CRP at age 6 months (n = 613) in COPSAC2010: −0.004 (−0.008;−0.0004), p = 0.030, but this was not replicated in COPSAC2000. In this study, we found evidence of associations across timepoints of 25(OH)D concentrations from mid-pregnancy to infancy and through childhood and associations between hs-CRP levels during childhood, although with weak correlations. We also found a negative cross-sectional association between 25(OH)D and hs-CRP concentrations in COPSAC2010 proposing a role of vitamin D in systemic low-grade inflammation, though this association was not present in COPSAC2000.
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