Hypocapnia is associated with increased upper airway expiratory resistance during sleep.
Hypocapnia is associated with increased upper airway expiratory resistance during sleep.
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DOI：
10.1016/j.resp.2011.04.004
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发表时间：
2011-07-31
影响因子：
2.3
通讯作者：
Badr, M. Safwan
中科院分区：
文献类型：
--
作者：
Sankri-Tarbichi, Abdul Ghani;Richardson, Nekeyua N.;Chowdhuri, Susmita;Rowley, James A.;Badr, M. Safwan
我们假设低碳酸血症是NREM睡眠期间呼气阻力增加的原因。低氧过度通气导致低碳酸血症21例（年龄29.4±7.8岁，女性10例，BMI 24.4±4.3 kg/m2）。12例受试者被诱导异碳酸缺氧，其中6例在当晚发生低碳酸缺氧。在吸气和呼气时按压力-流量线性关系测量上呼吸道阻力。吸气流量限制（IFL）被定义为压力-流量关系的分离。(1)与对照组相比，低碳酸血症时呼气RUA增加，而异碳酸血症时则没有增加（分别为11.0±5.6 vs. 8.2±3.6 cmH2O/L/s, p<0.05, 11.4±5.0 vs. 10.9±4.4 cmH2O/L/s, p=NS）。(2) RUA无性别差异（p=NS）。(3)低碳缺氧时呼气RUA增加与IFL变化相关，而与等碳缺氧无关。(4)吸入RUA和IFL未见变化。低碳酸血症时呼气RUA增加，与IFL相关，表明上气道狭窄。性别不影响上呼吸道对低碳酸血症缺氧的反应。
We hypothesized that hypocapnia is responsible for increased expiratory resistance during NREM sleep. Hypocapnia was induced by hypoxic hyperventilation in 21 subjects (aged 29.4 ±7.8 yrs, 10 women, BMI 24.4±4.3 kg/m2). Isocapnic hypoxia was induced in 12 subjects of whom, 6 underwent hypocapnic hypoxia in the same night. Upper airway resistance (RUA) was measured at the linear pressure-flow relationship during inspiration and expiration. Inspiratory flow limitation (IFL) was defined as the dissociation in pressure-flow relationship. (1) Expiratory RUA increased during hypocapnic but not isocapnic hypoxia relative to control (11.0±5.6 vs. 8.2±3.6 cmH2O/L/s; p<0.05, and 11.4±5.0 vs. 10.9±4.4 cmH2O/L/s; p=NS, respectively). (2) No gender difference was found in RUA (p=NS). (3) Increased expiratory RUA correlated with the IFL change during hypocapnic but not isocapnic hypoxia. (4) No changes were noted in inspiratory RUA or IFL. Expiratory RUA increased during hypocapnia and was associated with IFL, indicating upper airway narrowing. Gender does not influence the upper airway response to hypocapnic hypoxia.
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影响因子：
3.3
作者：
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